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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin
Virology, Volume 376, No. 2, Year 2008
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Description
The addition of oligosaccharide side chains to influenza virus hemagglutinin (HA) is believed to facilitate viral escape from immune pressure in the human population. To determine the implicit potentials for acquisition of N-linked glycosylation, we analyzed the genetic background of 16 subtypes of avian influenza virus, some of which may be potential pandemic viruses in the future. We found a significant difference among HA subtypes in their genomic sequences to produce N-glycosylation sites. Notably, recently circulating avian influenza viruses of the H5 and H9 subtypes may have rather greater capacities to undergo mutations associated with glycosylation of HA than past pandemic viruses. We hypothesize that influenza viruses maintained in natural reservoirs could have different potentials for sustained circulation, depending on their HA subtypes, if introduced into the human population. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Igarashi, Manabu
Japan, Sapporo
Hokkaido University
Ito, Kimihito
Japan, Sapporo
Hokkaido University
Kida, Hiroshi
Japan, Sapporo
Hokkaido University
Japan, Sapporo
Oie Reference Laboratory for Highly Pathogenic Avian Influenza
Takada, Ayato
Japan, Sapporo
Hokkaido University
Statistics
Citations: 68
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.virol.2008.03.036
ISSN:
10960341
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study