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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prevalence rates for dementia and Alzheimer's disease in African Americans: 1992 versus 2001
Alzheimer's and Dementia, Volume 5, No. 3, Year 2009
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Description
Background: This study compares age-specific and overall prevalence rates for dementia and Alzheimer's disease (AD) in two nonoverlapping, population-based cohorts of elderly African Americans in Indianapolis in 2001 and 1992. Methods: We used a two-stage design. The first stage involves the Community Screening Interview for Dementia (CSI-D). The CSI-D scores are grouped into good, intermediate, and poor performance before selection for clinical assessment. Diagnoses were performed using standard criteria in a consensus diagnosis conference; clinicians were blind to performance groups. In 1992, interviewers visited randomly sampled addresses to enroll self-identified African Americans aged ≥65 years. Of 2582 eligible, 2212 enrolled (9.6% refused, and 4.7% were too sick). In 2001, Medicare rolls were used for African Americans aged >70 years. Of 4260 eligible, 1892 (44%) enrolled, 1999 (47%) refused, and the remainder did not participate for other reasons. Results: The overall age-adjusted prevalence rate for dementia at age ≥70 years in 2001 was 7.45% (95 confidence interval [CI], 4.27-10.64), and in the 1992 cohort, this prevalence rate was 6.75% (95% CI, 5.77-7.74). The overall age-adjusted prevalence rate at age ≥70 years for AD in the 2001 cohort was 6.77% (95% CI, 3.65-9.90), and for the 1992 cohort, it was 5.47% (95% CI, 4.51-6.42). Rates for dementia and AD were not significantly different in the two cohorts (dementia, P = .3534; AD, P = .2649). Conclusions: We found no differences in the prevalence rates of dementia and AD between 1992 and 2001, despite significant differences in medical history and medical treatment within these population-based cohorts of African American elderly. © 2009 The Alzheimer's Association.
Authors & Co-Authors
Hall, Kathleen S.
United States, Indianapolis
Indiana University School of Medicine
Gao, Sujuan
United States, Indianapolis
Indiana University School of Medicine
Baiyewu, Olusegun
Nigeria, Ibadan
University of Ibadan
Lane, Kathleen A.
United States, Indianapolis
Indiana University School of Medicine
Gureje, Oye
Nigeria, Ibadan
University of Ibadan
Shen, Jianzhao
United States, Indianapolis
Indiana University School of Medicine
United States, Wilmington
Pharmaceutical Product Development, Llc.
Ogunniyi, Adesola O.
Nigeria, Ibadan
University of Ibadan
Murrell, Jill R.
United States, Indianapolis
Indiana University School of Medicine
Unverzagt, Frederick W.
United States, Indianapolis
Indiana University School of Medicine
Dickens, Jeanne
United States, Indianapolis
Indiana University School of Medicine
United States, South Bend
Madison Center
Smith-Gamble, Valerie
United States, Indianapolis
Indiana University School of Medicine
United States, Indianapolis
Richard L. Roudebush Vamc
Hendrie, Hugh C.
United States, Indianapolis
Indiana University School of Medicine
Statistics
Citations: 73
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1016/j.jalz.2009.01.026
Research Areas
Disability
Mental Health
Study Design
Cross Sectional Study
Cohort Study