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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
The impact of single versus mixed Schistosoma haematobium and S. mansoni infections on morbidity profiles amongst school-children in Taveta, Kenya
Acta Tropica, Volume 128, No. 2, Year 2013
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Description
Two schistosome species-. Schistosoma haematobium and S. mansoni-with two very different pathological profiles (urogenital versus intestinal), are responsible for the majority of human schistosomiasis infections across sub-Saharan Africa. The aim of this study was to determine whether coinfections have an impact on species-specific morbidity measures when compared to single species infections. Children from two neighbouring schools in Taveta, Kenya were grouped by infection status, i.e. uninfected, single species infections or coinfected. Clinical examination of the liver and spleen by palpation was performed and urinary albumin levels were recorded at baseline and at 12 months after praziquantel administration. Additional ultrasonographic profiles of the children's liver, spleen and bladder were incorporated at follow-up. It was found that S. haematobium-associated urogenital morbidity was lower in the coinfected group relative to single S. haematobium infections, even when infection intensities were taken into account. We also observed an association between S. haematobium infection and liver (intestinal-associated) morbidity regardless of coinfections. The findings reported here suggest that further research should be performed on the impact of S. haematobium infections on liver morbidity as well as to determine the impact of mixed schistosome species infections on human morbidity outcomes across different endemic settings. © 2013 Elsevier B.V.
Authors & Co-Authors
Gouvras, Anouk N.
United Kingdom, London
Imperial College London
Kariuki, Curtis H.
Kenya, Nairobi
National Museums of Kenya
Kenya, Meru
Kenya Methodist University
Koukounari, Artemis
United Kingdom, London
Medical Research Council
Norton, Alice J.
United Kingdom, London
Imperial College London
United Kingdom, London
Wellcome Trust
Lange, Charles N.
Kenya, Nairobi
National Museums of Kenya
Ireri, Edmund
Kenya, Nairobi
Kenya Medical Research Institute
Fenwick, Alan
United Kingdom, London
Imperial College London
Mkoji, Gerald M.
Kenya, Nairobi
Kenya Medical Research Institute
Webster, Joanne P.
United Kingdom, London
Imperial College London
Statistics
Citations: 32
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1016/j.actatropica.2013.01.001
ISSN:
0001706X
e-ISSN:
18736254
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Kenya