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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Freeze-thaw lysates of Plasmodium falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells
European Journal of Immunology, Volume 42, No. 7, Year 2012
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Description
In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to TCR stimulation with cytokine costimulation. Using these artificial stimulation conditions, both naïve as well as memory CD4+ T cells can be converted into induced Treg (iTreg) cells, but the cellular origin of such iTreg cells in vivo or in response to more physiologic stimulation with pathogen-derived antigens is less clear. Here, we demonstrate that a freeze/thaw lysate of Plasmodium falciparum schizont extract (PfSE) can induce functionally competent Treg cells from peripheral lymphocytes in a time- and dose-dependent manner without the addition of exogenous costimulatory factors. The PfSE-mediated induction of Treg cells required the presence of nTreg cells in the starting culture. Further experiments mixing either memory or naïve T cells with antigen presenting cells and CFSE-labeled Treg cells identified CD4+CD45RO+CD25- memory T cells rather than Treg cells as the primary source of PfSE-induced Treg cells. Taken together, these data suggest that in the presence of nTreg cells, PfSE induces memory T cells to convert into iTreg cells that subsequently expand alongside PfSE-induced effector T cells. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3549566/bin/eji0042-1767-SD1.pdf
Authors & Co-Authors
Finney, Olivia C.
Unknown Affiliation
Lawrence, Emma
Unknown Affiliation
Gray, Alice P.
Unknown Affiliation
Njie, Madi
Unknown Affiliation
Riley, Eleanor M.
Unknown Affiliation
Walther, Michael
Unknown Affiliation
Statistics
Citations: 11
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1002/eji.201142164
e-ISSN:
15214141