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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice
Journal of Medicinal Food, Volume 9, No. 4, Year 2006
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Description
Vernonia amygdalina Del. (Family Compositae) is used in Nigerian folk medicine as a tonic and remedy against constipation, fever, high blood pressure, and many infectious diseases. We have evaluated the hepatoprotective and antioxidant effects of an aqueous extract of V. amygdalina leaves against acetaminophen-induced hepatotoxicity and oxidative stress in mice in vivo. Activities of liver marker enzymes in serum (glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase, lactate dehydrogenase, and alkaline phosphatase) and bilirubin levels were determined colorimetrically, while catalase activity, lipid peroxidation products, thiobarbituric acid-reactive substances (TBARS), iron, and total protein concentrations were measured in liver homogenate. Acetaminophen challenge (300 mg/kg, i.p) for 7 days caused significant (P < .01) increases in the levels of bilirubin, liver enzymes, TBARS, and iron, while catalase activity and total protein level were reduced significantly (P < .01). Preadministration of V. amygdalina resulted in a dose-dependent (50-100 mg/kg) reversal of acetaminophen-induced alterations of all the liver function parameters by 51.9-84.9%. Suppression of acetaminophen-induced lipid peroxidation and oxidative stress by the extract was also dose-dependent (50-100 mg/kg). The results of this study suggest that V. amygdalina elicits hepatoprotectivity through antioxidant activity on acetaminophen-induced hepatic damage in mice. © Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition.
Authors & Co-Authors
Iwalokun, Bamidele Abiodun
Nigeria, Lagos
Lagos State University
Efedede, B. U.
Nigeria, Lagos
Lagos State University
Alabi-Sofunde, J. A.
Nigeria, Lagos
Lagos State University
Oduala, T.
Nigeria, Lagos
Lagos State University
Magbagbeola, Olubunmi A.
Nigeria, Lagos
University of Lagos
Akinwande, A. I.
Nigeria, Lagos
University of Lagos
Statistics
Citations: 142
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1089/jmf.2006.9.524
ISSN:
1096620X
Research Areas
Food Security
Health System And Policy
Noncommunicable Diseases