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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults
Journal of Infection, Volume 72, No. 4, Year 2016
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Description
Bacterial meningitis and meningococcal sepsis are rare conditions with high case fatality rates. Early recognition and prompt treatment saves lives. In 1999 the British Infection Society produced a consensus statement for the management of immunocompetent adults with meningitis and meningococcal sepsis.Since 1999 there have been many changes. We therefore set out to produce revised guidelines which provide a standardised evidence-based approach to the management of acute community acquired meningitis and meningococcal sepsis in adults.A working party consisting of infectious diseases physicians, neurologists, acute physicians, intensivists, microbiologists, public health experts and patient group representatives was formed. Key questions were identified and the literature reviewed. All recommendations were graded and agreed upon by the working party. The guidelines, which for the first time include viral meningitis, are written in accordance with the AGREE 2 tool and recommendations graded according to the GRADE system.Main changes from the original statement include the indications for pre-hospital antibiotics, timing of the lumbar puncture and the indications for neuroimaging. The list of investigations has been updated and more emphasis is placed on molecular diagnosis. Approaches to both antibiotic and steroid therapy have been revised. Several recommendations have been given regarding the follow-up of patients. © 2016 The Authors.
Authors & Co-Authors
McGill, Fiona
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
United Kingdom, Leeds
Leeds Teaching Hospitals Nhs Trust
Heyderman, Robert Simon
United Kingdom, London
University College London
Michael, Benedict Daniel
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
The Walton Centre Nhs Foundation Trust
Defres, Sylviane
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
United Kingdom, Dundee
Nhs Tayside
Beeching, Nicholas J.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Borrow, Ray
United Kingdom, London
Public Health England
Glennie, Linda
United Kingdom, Bristol
Meningitis Research Foundation
Kaczmarski, Edward B.
United Kingdom, London
Public Health England
Nadel, Simon
United Kingdom, London
St Mary's Hospital
United Kingdom, London
Imperial College London
United Kingdom, Bristol
Meningitis Research Foundation
Thwaites, G. E.
United Kingdom, Oxford
University of Oxford
Viet Nam, Ho Chi Minh City
Oxford University Clinical Research Unit
Davies, Nicholas W.S.
United Kingdom, London
Chelsea and Westminster Hospital Nhs Foundation Trust
Rhodes, Andrew
United Kingdom, London
St George's University Hospitals Nhs Foundation Trust
Read, Robert Charles
United Kingdom, Southampton
University of Southampton
United Kingdom, Southampton
University Hospital Southampton Nhs Foundation Trust
Solomon, Tom
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
United Kingdom, Liverpool
The Walton Centre Nhs Foundation Trust
Statistics
Citations: 143
Authors: 14
Affiliations: 22
Identifiers
Doi:
10.1016/j.jinf.2016.01.007
ISSN:
01634453
Research Areas
Health System And Policy
Study Design
Cohort Study