Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Nephroprotective effect of date fruit extract against dichloroacetic acid exposure in adult rats
Food and Chemical Toxicology, Volume 65, Year 2014
Notification
URL copied to clipboard!
Description
The aim of this study was to investigate the protective effects of aqueous date extract (ADE) on dichloroacetic acid (DCA)-induced nephrotoxicity. In vitro, total phenolic content estimated in the ADE were 417.71. mg gallic acid equivalents/100. g fresh weights (FW), while total flavonoid and tannins contents were 285.23 and 73.65. mg catechin equivalents/100. g FW, respectively. The ADE has strong scavenging activity. Ferulic, caffeic and p-coumaric acids are the major's compounds. Nephrotoxicity was induced in male Wistar rats by the administration of 0.5 and 2. g/L DCA as drinking water. Some of these rats received also by gavage ADE (4. mL/kg) before the administration of DCA. After two months of experiment, DCA administration caused elevated levels of renal MDA, significant depletion of GSH levels, altered the antioxidant enzyme activities and deteriorated the renal functions as assessed by the increased plasma urea, uric acid and creatinine levels compared to control rats. The treatment with the ADE significantly normalized the increased plasma levels of creatinine, urea and uric acid, reduced the elevated MDA levels, significantly normalized the antioxidant enzyme activities and GSH level and restored the altered kidney histology in rats treated with DCA. Therefore, it was speculated that ADE protects rats from kidney damage through its antioxidant capacity. © 2013 Elsevier Ltd.
Authors & Co-Authors
El Arem, Amira
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Thouri, Amira
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Zekri, Mouna
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Saafi, Emna Behija
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Ghrairi, Fatma
Tunisia, Sousse
Faculty of Medicine Sousse
Zakhama, Abdelfattah
Tunisia, Monastir
Chu Fattouma-bourguiba
Achour, Lotfi
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Statistics
Citations: 24
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.fct.2013.12.023
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Environmental
Study Approach
Quantitative
Participants Gender
Male