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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Protective mechanisms of helminths against reactive oxygen species are highly promising drug targets
Current Medicinal Chemistry, Volume 21, No. 15, Year 2014
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Description
Helminths that are the causative agents of numerous neglected tropical diseases continue to be a major problem for human global health. In the absence of vaccines, control relies solely on pharmacoprophylaxis and pharmacotherapy to reduce transmission and to relieve symptoms. There are only a few drugs available and resistance in helminths of lifestock has been observed to the same drugs that are also used to treat humans. Clearly there is an urgent need to find novel antiparasitic compounds. Not only are helminths confronted with their own metabolically derived toxic and redox-active byproducts but also with the production of reactive oxygen species (ROS) by the host immune system, adding to the overall oxidative burden of the parasite. Antioxidant enzymes of helminths have been identified as essential proteins, some of them biochemically distinct to their host counterpart and thus appealing drug targets. In this review we have selected a few enzymatic antioxidants of helminths that are thought to be druggable. ©2014 Bentham Science Publishers.
Authors & Co-Authors
Perbandt, Markus
Germany, Hamburg
Universität Hamburg
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Ndjonka, Dieudonné
Cameroon, Ngaoundere
University of Ngaoundere
Liebau, Eva
Germany, Munich
Institute of Animal Physiology
Statistics
Citations: 6
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.2174/0929867320666131119122907
ISSN:
09298673
e-ISSN:
1875533X
Research Areas
Environmental