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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genetic diversity and phylogeographic clustering of SIVcpzPtt in wild chimpanzees in Cameroon
Virology, Volume 368, No. 1, Year 2007
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Description
It is now well established that the clade of simian immunodeficiency viruses (SIVs) infecting west central African chimpanzees (Pan troglodytes troglodytes) and western gorillas (Gorilla gorilla gorilla) comprises the progenitors of human immunodeficiency virus type 1 (HIV-1). In this study, we have greatly expanded our previous molecular epidemiological survey of SIVcpz in wild chimpanzees in Cameroon. The new results confirm a wide but uneven distribution of SIVcpzPtt in P. t. troglodytes throughout southern Cameroon and indicate the absence of SIVcpz infection in Pan troglodytes vellerosus. Analyzing 725 fecal samples from 15 field sites, we obtained partial nucleotide sequences from 16 new SIVcpzPtt strains and determined full-length sequences for two of these. Phylogenetic analyses of these new viruses confirmed the previously reported phylogeographic clustering of SIVcpzPtt lineages, with viruses related to the ancestors of HIV-1 groups M and N circulating exclusively in southeastern and south central P. t. troglodytes communities, respectively. Importantly, the SIVcpzPtt strains from the southeastern corner of Cameroon represent a relatively isolated clade indicating a defined geographic origin of the chimpanzee precursor of HIV-1 group M. Since contacts between humans and apes continue, the possibility of ongoing transmissions of SIV from chimpanzees (or gorillas) to humans has to be considered. In this context, our finding of distinct SIVcpzPtt envelope V3 sequence clades suggests that these peptides may be useful for the serological differentiation of SIVcpzPtt and HIV-1 infections, and thus the diagnosis of new cross-species transmissions if they occurred. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Heuverswyn, Fran Van
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Li, Yingying
United States, Birmingham
The University of Alabama at Birmingham
Bailes, Elizabeth
United Kingdom, Nottingham
University of Nottingham
Néel, Cécile
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Cameroon, Yaounde
Projet Prevention du Sida au Cameroun Presica
Lafay, Benedicte
France, Montpellier
Ird Centre de Montpellier
Keele, Brandon F.
United States, Birmingham
The University of Alabama at Birmingham
Shaw, Katharina S.
United States, Birmingham
The University of Alabama at Birmingham
Takehisa, Jun
United States, Birmingham
The University of Alabama at Birmingham
Kraus, Matthias H.
United States, Birmingham
The University of Alabama at Birmingham
Loul, Sévérin
Cameroon, Yaounde
Projet Prevention du Sida au Cameroun Presica
Butel, Christelle
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Liégeois, Florian
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Yangda, Bienvenue
Cameroon, Yaounde
Projet Prevention du Sida au Cameroun Presica
Sharp, Paul M.
United Kingdom, Nottingham
University of Nottingham
Mpoudi-Ngolé, Eitel
Cameroon, Yaounde
Projet Prevention du Sida au Cameroun Presica
Delaporte, Éric
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
France, Montpellier
Centre Hospitalier Universitaire de Montpellier
Hahn, Beatrice H.
United States, Birmingham
The University of Alabama at Birmingham
Peeters, Martine F.
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Statistics
Citations: 18
Authors: 18
Affiliations: 6
Identifiers
Doi:
10.1016/j.virol.2007.06.018
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Cameroon