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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Immunologic response in treatment-naïve HIV-2-infected patients: The IeDEA West Africa cohort
Journal of the International AIDS Society, Volume 19, No. 1, Article 20044, Year 2016
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Description
Introduction: Response to antiretroviral therapy (ART) among individuals infected with HIV-2 is poorly described. We compared the immunological response among patients treated with three nucleoside reverse-transcriptase inhibitors (NRTIs) to boosted protease inhibitor (PI) and unboosted PI-based regimens in West Africa. Methods: This prospective cohort study enrolled treatment-naïve HIV-2-infected patients within the International Epidemiological Databases to Evaluate AIDS collaboration in West Africa. We used mixed models to compare the CD4 count response to treatment over 12 months between regimens. Results: Of 422 HIV-2-infected patients, 285 (67.5%) were treated with a boosted PI-based regimen, 104 (24.6%) with an unboosted PI-based regimen and 33 (7.8%) with three NRTIs. Treatment groups were comparable with regard to gender (54.5% female) and median age at ART initiation (45.3 years; interquartile range 38.3 to 51.8). Treatment groups differed by clinical stage (21.2%, 16.8% and 17.3% at CDC Stage C or World Health Organization Stage IV for the triple NRTI, boosted PI and unboosted PI groups, respectively, p = 0.02), median length of follow-up (12.9, 17.7 and 44.0 months for the triple NRTI, the boosted PI and the unboosted PI groups, respectively, p<0.001) and baseline median CD4 count (192, 173 and 129 cells/μl in the triple NRTI, the boosted PI and the unboosted PI-based regimen groups, respectively, p = 0.003). CD4 count recovery at 12 months was higher for patients treated with boosted PI-based regimens than those treated with three NRTIs or with unboosted PI-based regimens (191 cells/μl, 95% CI 142 to 241; 110 cells/μl, 95% CI 29 to 192; 133 cells/μl, 95% CI 80 to 186, respectively, p = 0.004). Conclusions: In this observational study using African data, boosted PI-containing regimens had better immunological response compared to triple NRTI combinations and unboosted PI-based regimens at 12 months. A randomized clinical trial is still required to determine the best initial regimen for treating HIV-2 infected patients. © 2016 Balestre E et al.
Authors & Co-Authors
Balestre, Eric
France, Bordeaux
Bordeaux Population Health Research Center Bph
Ékouévi, Didier Koumavi
France, Bordeaux
Bordeaux Population Health Research Center Bph
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Tchounga, Boris Kévin
France, Bordeaux
Bordeaux Population Health Research Center Bph
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Eholié, Serge Paul
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Messou, Eugéne
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Cote D'ivoire, Abidjan
Yopougon Attié Hospital
Cote D'ivoire, Abidjan
Cepref-enfants
Sawadogo, Adrien
Burkina Faso, Bobo-dioulasso
Université Nazi Boni
Thíébaut, Rodolphe
France, Bordeaux
Bordeaux Population Health Research Center Bph
May, Margaret T.
United Kingdom, Bristol
University of Bristol
Sterne, Jonathan A.C.
United Kingdom, Bristol
University of Bristol
Dabis, Franćois Ç.Ois
France, Bordeaux
Bordeaux Population Health Research Center Bph
Zannou, Djimon Marcel
Benin, Cotonou
Cnhu Hubert Maga
Ahouada, Carin
Benin, Cotonou
Cnhu Hubert Maga
Akakpo, Jocelyn
Benin, Cotonou
Cnhu Hubert Maga
Ahomadégbé, Christelle
Benin, Cotonou
Cnhu Hubert Maga
Bashi, Jules B.
Benin, Cotonou
Cnhu Hubert Maga
Gougounon-Houêto, Alice
Benin, Cotonou
Cnhu Hubert Maga
Azon-Kouanou, Angèle
Benin, Cotonou
Cnhu Hubert Maga
Houngbè, Fabien
Benin, Cotonou
Cnhu Hubert Maga
Séhonou, Jean J.
Benin, Cotonou
Cnhu Hubert Maga
Koumakpaï, Sikiratou A.
Benin, Cotonou
Cnhu Hubert Maga
Alihonou, Florence
Benin, Cotonou
Cnhu Hubert Maga
D'Almeida, Marcelline
Benin, Cotonou
Cnhu Hubert Maga
Hodonou, Irvine
Benin, Cotonou
Cnhu Hubert Maga
Hounhoui, Ghislaine
Benin, Cotonou
Cnhu Hubert Maga
Sagbo, Gracien
Benin, Cotonou
Cnhu Hubert Maga
Tossa-Bagnan, Leïla
Benin, Cotonou
Cnhu Hubert Maga
Adjide, Herman
Benin, Cotonou
Cnhu Hubert Maga
Drabo, Joseph Youssouf
Burkina Faso, Ouagadougou
Chu Yalgado
Bognounou, René
Burkina Faso, Ouagadougou
Chu Yalgado
Diendéré, Arnaud Eric
Burkina Faso, Ouagadougou
Chu Yalgado
Traore, Eliezer
Burkina Faso, Ouagadougou
Chu Yalgado
Zoungrana, Lassané A.
Burkina Faso, Ouagadougou
Chu Yalgado
Zerbo, Béatrice
Burkina Faso, Ouagadougou
Chu Yalgado
Sawadogo, Adrien Bruno
Burkina Faso, Bobo-dioulasso
Chu Sourô Sanou
Zoungrana, Jacques
Burkina Faso, Bobo-dioulasso
Chu Sourô Sanou
Héma, Arsène
Burkina Faso, Bobo-dioulasso
Chu Sourô Sanou
Soré, Ibrahim
Burkina Faso, Bobo-dioulasso
Chu Sourô Sanou
Bado, Guillaume
Burkina Faso, Bobo-dioulasso
Chu Sourô Sanou
Tapsoba, Achille
Burkina Faso, Bobo-dioulasso
Chu Sourô Sanou
Yé, Diarra
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Kouéta, Fla
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Ouédraogo, Sylvie Armelle P.
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Ouédraogo-Traoré, Rasmata
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Hiembo, William
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Gansonré, Mady
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Gnokoro, Joachim Charles
Cote D'ivoire, Abidjan
Cepref-enfants
Koné, Mamadou
Cote D'ivoire, Abidjan
Cepref-enfants
Kouakou, Guillaume Martial
Cote D'ivoire, Abidjan
Cepref-enfants
Bosse, Clarisse Amani
Cote D'ivoire, Abidjan
Centre Mtct-plus
Brou, Kouakou J.
Cote D'ivoire, Abidjan
Centre Mtct-plus
Assi, Achi Isidore
Cote D'ivoire, Abidjan
Centre Mtct-plus
Chenal, Henri
Cote D'ivoire, Abidjan
Cirba
Hawerlander, Denise
Cote D'ivoire, Abidjan
Cirba
Soppi, Franck
Cote D'ivoire, Abidjan
Cirba
Minga, Albert Kla
Cote D'ivoire, Abidjan
Cmsds/cnts
Abo, Yao
Cote D'ivoire, Abidjan
Cmsds/cnts
Yoboue, Jean Michel
Cote D'ivoire, Abidjan
Cmsds/cnts
Deborah, Mensah
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Amego, Noelly
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Andavi, Viviane
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Diallo, Zélica
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Ello, Frêdéric Nogbou
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Tanon, Aristophane Koffi
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Koulé, Serge Olivier
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Anzan, Koffi Charles
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Guéhi, Calixte
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Aka, Edmond Addi
Cote D'ivoire, Abidjan
Cepref-enfants
Issouf, Koffi Ladji
Cote D'ivoire, Abidjan
Cepref-enfants
Kouakou, Jean Claude
Cote D'ivoire, Abidjan
Cepref-enfants
N'Gbeche, Marie Sylvie
Cote D'ivoire, Abidjan
Cepref-enfants
Pety, Touré
Cote D'ivoire, Abidjan
Centre Mtct-plus
Avit-Edi, Divine
Cote D'ivoire, Abidjan
Centre Mtct-plus
Kouakou, Kouadio P.
Cote D'ivoire, Abidjan
Cirba
Moh, Magloire
Cote D'ivoire, Abidjan
Cirba
Yao, Valérie Andoblé
Cote D'ivoire, Abidjan
Cirba
Folquet, Madeleine Amorissani
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Dainguy, Marie Evelyne
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Kouakou, Cyrille
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Méa-Assandé, Véronique Tanoh
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Oka-Bérété, Gladys
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Zobo, Nathalie
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Acquah, Patrick
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Kokora, Marie Berthe
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Eboua, Tanoh François
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
Timité-Konan, Marguerite
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
Ahoussou, Lucrèce Diecket
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
Assouan, Julie Kebé
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
Sami, Mabéa Flora
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
Kouadio, Clémence
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
A Renner, Lorna
Ghana, Accra
Korle bu Hospital
Goka, Bamenla Quarm
Ghana, Accra
Korle bu Hospital
Welbeck, Jennifer E.
Ghana, Accra
Korle bu Hospital
Sackey, Adziri Harold
Ghana, Accra
Korle bu Hospital
Owiafe, Seth Ntiri
Ghana, Accra
Korle bu Hospital
Wejse, Christian
Guinea-bissau, Bissau
Bandim Health Project
da Silva, Zacarias José
Guinea-bissau, Bissau
Bandim Health Project
Paulo, Joao
Guinea-bissau, Bissau
Bandim Health Project
Rodrigues, Amabélia
Guinea-bissau, Bissau
Bandim Health Project
da Silva, David
Guinea-bissau
National Hiv Programme
Medina, Candida
Guinea-bissau
Hospital National Simao Mendes
Oliviera-Souto, Ines
Guinea-bissau, Bissau
Bandim Health Project
Østergaard, Lars Jørgen
Denmark, Aarhus
Aarhus Universitetshospital
Laursen, Alex Lund
Denmark, Aarhus
Aarhus Universitetshospital
Sodemann, Morten
Denmark, Odense
Odense Universitetshospital
Aaby, Peter
Guinea-bissau, Bissau
Bandim Health Project
Fomsgaard, Anders
Denmark, Copenhagen
Statens Serum Institut
Erikstrup, Christian
Unknown Affiliation
Eugen-Olsen, Jesper
Denmark, Hvidovre
Hvidovre Hospital
Maïga, Moussa Youssouffa
Mali, Bamako
Gabriel Toure Hospital
Kallé, Abdoulaye
Mali, Bamako
Gabriel Toure Hospital
Katilé, Drissa
Mali, Bamako
Gabriel Toure Hospital
Traoré, Hammar Alassane
Mali, Bamako
Point g Hospital
Minta, Daouada K.
Mali, Bamako
Point g Hospital
Cissé, Tidiani
Mali, Bamako
Point g Hospital
Dembélé, Mamadou Y.
Mali, Bamako
Point g Hospital
Fomba, Mahamadou
Mali, Bamako
Point g Hospital
Kaya, Assêtou Soukho
Mali, Bamako
Point g Hospital
Traoré, Abdoulaye Mamadou
Mali, Bamako
Point g Hospital
Traoré, Hamady H.
Mali, Bamako
Point g Hospital
Touré, Amadou Abathina
Mali, Bamako
Point g Hospital
Dicko-Traoré, Fatoumata B.
Mali, Bamako
Gabriel Toure Hospital
Sylla, Mariam Moustapha
Mali, Bamako
Gabriel Toure Hospital
Koné, Niaboula
Mali, Bamako
Gabriel Toure Hospital
N'Diaye, Clémentine
Mali, Bamako
Gabriel Toure Hospital
Traoré, Mamadou M.
Mali, Bamako
Gabriel Toure Hospital
Charurat, Man
Unknown Affiliation
Kwaghe, Vivian Gga
Nigeria, Abuja
Uath
Ajayi, Samuel Oluwole
Nigeria, Abuja
Uath
Dapiap, Stephen B.
Nigeria, Abuja
Uath
Igbinoba, Festus
Nigeria, Abuja
National Hospital, Abuja
Benson, Okwara
Nigeria, Benin
Ubth
Adebamowo, Clement
Nigeria, Benin
Ubth
Seydi, Moussa
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Sow, Papa Salif
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Diop, Bernard Marcel
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Manga, Noël Magloire
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Tine, Judicaël Malick
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Bassabi, Coumba Cissé
Senegal, Dakar
Centre Hospitalier Universitaire Dakar
Sy, Haby Signaté
Senegal, Dakar
Albert Royer Hospital
Ba, Abou
Senegal, Dakar
Albert Royer Hospital
Dior, Hélène
Senegal, Dakar
Albert Royer Hospital
Faye, Malick L.
Senegal, Dakar
Albert Royer Hospital
Gueye, Ramatoulaye Diagne
Senegal, Dakar
Albert Royer Hospital
Mbaye, Aminata Diack
Senegal, Dakar
Albert Royer Hospital
Patassi, Akouda Akessiwe
Togo, Lome
Centre Hospitalier Universitaire Tokoin
Kotosso, Awerou
Togo, Lome
Centre Hospitalier Universitaire Tokoin
Gbadamassi, Gafarou
Togo, Lome
Centre Hospitalier Universitaire Tokoin
Lawson-Évi, Koko
Togo, Lome
Centre Hospitalier Universitaire Tokoin
Atakouma, Yawo Dzayissè
Togo, Lome
Centre Hospitalier Universitaire Tokoin
Takassi, Elom Ounoo
Togo, Lome
Centre Hospitalier Universitaire Tokoin
Bissagnéné, Emmanuel
Unknown Affiliation
Arrivé, Élise
Unknown Affiliation
Coffié, Patrick Ahuatchi
Unknown Affiliation
Jaquet, Antoine
Unknown Affiliation
Leroy, Valeriane
Unknown Affiliation
Sasco, Annie Jeanne
Unknown Affiliation
Lewden, Charlotte
Unknown Affiliation
Azani, Jean Claude
Unknown Affiliation
Bessekon, Serge
Unknown Affiliation
Karcher, Sophie
Unknown Affiliation
Gonsan, Jules Mahan
Unknown Affiliation
Le Carrou, Jérôme
Unknown Affiliation
Lenaud, Sêverin
Unknown Affiliation
Nchot, Célestin
Unknown Affiliation
Malateste, Karen
Unknown Affiliation
Cissé, Abdoulaye
Unknown Affiliation
Doring, Alexandra
Unknown Affiliation
Kouakou, Adrienne V.
Unknown Affiliation
Rabourdin, Elodie
Unknown Affiliation
Anglaret, Xavier
Unknown Affiliation
Ba, Boubacar
Unknown Affiliation
Becquet, Renaud
Unknown Affiliation
Essanin, Jean Bosco
Unknown Affiliation
Ciaranello, Andrea L.
Unknown Affiliation
Datté, Sébastien Atta
Unknown Affiliation
Desmonde, Sophie
Unknown Affiliation
Diby, Jean Serge Elvis
Unknown Affiliation
Horo, Apollinaire Gninlgninrin
Unknown Affiliation
Jesson, Julie
Unknown Affiliation
Meless, David Guanga
Unknown Affiliation
Mounkaila-Harouna, Aïda
Unknown Affiliation
Ndondoki, Camille
Unknown Affiliation
Shiboski, Caroline H.
Unknown Affiliation
Wandeler, Gilles
Unknown Affiliation
Statistics
Citations: 18
Authors: 184
Affiliations: 33
Identifiers
Doi:
10.7448/IAS.19.1.20044
ISSN:
17582652
Research Areas
Infectious Diseases
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative
Study Locations
Multi-countries
Participants Gender
Female