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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Protective effect of methanol-methylene chloride extract of Terminalia glaucescens leaves on streptozotocin-induced diabetes in mice
Tropical Journal of Pharmaceutical Research, Volume 8, No. 1, Year 2009
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Description
Purpose: Terminalia glaucescens (Combretaceae) is traditionally used in Cameroon in the treatment of diabetes. The anti-hyperglycemic effect of the methanol-methylene chloride extract of the leaves of this plant was investigated in streptozotocin (STZ)-induced diabetic mice. Methods: Diabetes was induced in mice by a daily dose of STZ (45 mg kg-1 body weight i.p.) for 5 days. From one day before STZ injection, normal and diabetic-test mice received one oral dose of the extract (100 mg kg-1 or 300 mg kg-1 body weight) daily for 15 days. The effect of the extract on body weight gain, food and water intake, plasma metabolites (glucose and lipids) and insulin levels was investigated. Results: Diabetic control mice and diabetic mice pre-treated with 100 mg kg-1 extract showed body weight loss, marked (P< 0.001) polyphagia and polydipsia, high plasma metabolites and glucose (P< 0.001), non-esterified fatty acids (NEFA) (P< 0.05), triglycerides (TG) (P< 0.05), and cholesterol (P< 0.05) and low insulin (P< 0.001) levels. Normal control, i.e., normal treated mice and 300 mg kg-1 extract pre-treated diabetic mice, presented normal weight gain, normal food and water intake, normal plasma metabolites and insulin levels, and did not exhibit very significant changes (P<0.1) in blood glucose level.. Conclusion: These results indicate that the extract of T. glaucescens leaf at a dose of 300 mg kg-1 protects against STZ-induced diabetic effects and could explain the traditional use of this plant in the management of diabetes. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin. All rights reserved.
Authors & Co-Authors
Njomen, Guy B.S.N.
Cameroon, Yaounde
Université de Yaoundé I
Kamgang, René
Cameroon, Yaounde
Université de Yaoundé I
Soua, Petit R.N.
Cameroon, Yaounde
Université de Yaoundé I
Oyono, Jean Louis Essamé
Cameroon, Yaounde
Université de Yaoundé I
Njikam, N.
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 10
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.4314/tjpr.v8i1.14708
ISSN:
15965996
e-ISSN:
15969827
Research Areas
Environmental
Food Security
Health System And Policy
Noncommunicable Diseases
Study Locations
Benin
Cameroon