Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
Proceedings of the National Academy of Sciences of the United States of America, Volume 103, No. 9, Year 2006
Notification
URL copied to clipboard!
Description
East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8+ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8+ CTL from immune cattle. CD8+ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naïve cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites. © 2006 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1413922/bin/pnas_0511273103_index.html
Authors & Co-Authors
Graham, Simon P.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Pellé, Roger
Kenya, Nairobi
International Livestock Research Institute Nairobi
Honda, Yoshikazu
Kenya, Nairobi
International Livestock Research Institute Nairobi
Mwangi, Duncan M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Tonukari, Nyerhovwo John
Kenya, Nairobi
International Livestock Research Institute Nairobi
Nigeria, Abraka
Delta State University Nigeria
Yamage, Mat
Kenya, Nairobi
International Livestock Research Institute Nairobi
Glew, E. Jane
Kenya, Nairobi
International Livestock Research Institute Nairobi
United Kingdom, Teddington
Lgc Ltd.
De Villiers, Etienne P.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Shah, Trushar M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Bishop, Richard Peter
Kenya, Nairobi
International Livestock Research Institute Nairobi
Abuya, Evelyne
Kenya, Nairobi
International Livestock Research Institute Nairobi
Awino, Elias
Kenya, Nairobi
International Livestock Research Institute Nairobi
Gachanja, James N.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Luyai, Anthony E.
Kenya, Nairobi
International Livestock Research Institute Nairobi
United States, Oklahoma City
University of Oklahoma Health Sciences Center
Mbwika, Ferdinand
Kenya, Nairobi
International Livestock Research Institute Nairobi
Muthiani, Anthony M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Ndegwa, David M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
United States, Grafton
Cummings School of Veterinary Medicine
Njahira, Moses Ndotono
Kenya, Nairobi
International Livestock Research Institute Nairobi
Nyanjui, John K.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Onono, Fredrick O.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Germany, Hannover
Hannover Medical School
Osaso, Julius
Kenya, Nairobi
International Livestock Research Institute Nairobi
Saya, Rosemary M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Wildmann, Claude
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Fraser, Claire M.
United States, Rockville
J. Craig Venter Institute
Maudlin, Ian M.
United Kingdom, Roslin
The Royal Dick School of Veterinary Studies
Gardner, Malcolm J.
United States, Rockville
J. Craig Venter Institute
United States, Seattle
Seattle Biomedical Research Institute
Morzaria, Subhash P.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Thailand, Bangkok
Food and Agriculture Organization
Loosmore, Sheena
Canada, Toronto
Sanofi Pasteur
Gilbert, Sarah C.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Audonnet, Jean Christophe
Germany, Ingelheim am Rhein
Boehringer Ingelheim International Gmbh
Van Der Bruggen, Pierre
Belgium, Brussels
Ludwig Institute for Cancer Research Brussels
Nene, Vishvanath M.
United States, Rockville
J. Craig Venter Institute
Taracha, Evans L.N.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Statistics
Citations: 136
Authors: 33
Affiliations: 14
Identifiers
Doi:
10.1073/pnas.0511273103
ISSN:
00278424
Research Areas
Cancer