Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antibodies to epstein-barr virus in burkitt's lymphoma and control groups
Journal of the National Cancer Institute, Volume 43, No. 5, Year 1969
Notification
URL copied to clipboard!
Description
Numerous sera from African patients with Burkitt's lymphomas (BL) or other malignant and nonmalignant diseases, as well as sera from various control populations, were titrated in indirect immuno-fluorescence tests for antibodies to the Epstein-Barr virus (EBV). The results reaffirmed the unusual frequency (87%) of high liters (≧1:160) among active BL patients. Although low titers (≦1:80) were found in some histologically confirmed cases, they were somewhat more frequent among a) patients whose diagnosis could not be confirmed or remained in doubt; b) long-term survivors; and c) patients first admitted when moribund. In contrast, sera were found among the control groups which failed to give positive reactions in dilution 1:10 (18% overall), only few (14%) had levels of ≧1:160, and the geometric mean titer was eightfold lower than that of the confirmed BL cases. The results were similar, whether the controls were: Children matched with patients as to age, sex, and tribe; siblings, other family members, and neighbors of patients; or randomly selected. From the age distribution of antibodies to EBV among the controls, it became evident that infections by EBV in East Africa occur in very young age groups at greater frequency than in the United States. Limited numbers of sera from patients with acute malaria, big spleen disease, tonsillitis, leprosy, reticulum cell sarcoma, Hodgkin's disease, or Kaposi's sarcoma yielded results like those seen in the various control groups. The implications of these findings regarding a possible etiologic relation of EBV to BL are discussed. © 1969, Oxford University Press.
Authors & Co-Authors
Henle, Gertrude E.
Unknown Affiliation
Henle, Werner
Unknown Affiliation
Clifford, Peter
Unknown Affiliation
Diehl, Volker
Unknown Affiliation
Kafuko, George W.
Unknown Affiliation
Kirya, Barnabas G.
Unknown Affiliation
Klein, George O.
Unknown Affiliation
Morrow, Richard H.
Unknown Affiliation
Munube, Germano M.R.
Unknown Affiliation
Ziegler, John L.
Unknown Affiliation
Statistics
Citations: 407
Authors: 10
Identifiers
Doi:
10.1093/jnci/43.5.1147
ISSN:
00278874
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Study Locations
Multi-countries