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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The COL5A1 genotype is associated with range of motion measurements
Scandinavian Journal of Medicine and Science in Sports, Volume 19, No. 6, Year 2009
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Description
There is an interest in identifying the intrinsic risk factors, including altered musculotendinous flexibility, that may be associated with musculotendinous injuries. We have recently shown that a sequence variant, namely the BstUI restriction fragment length polymorphism (RFLP), within the COL5A1 gene is associated with chronic Achilles tendinopathy. Mutations within COL5A1 have been implicated in Ehlers Danlos syndrome, a condition that is characterized by joint hypermobility. The aim of this study was to investigate the association of sequence variants within COL5A1 and musculotendinous range of motion (ROM). The sit and reach (SR) and the passive straight leg raise (SLR) were measured on 119 Caucasian subjects with either a past, current or no history of Achilles tendon injuries. The subjects were genotyped for four sequence variants within the 3′-UTR of the COL5A1 gene. Gender (P=0.016), age (P=0.011) and the BstUI RFLP (P=0.010) jointly contributed significantly to the optimal SLR model which accounted for 19.3% of the variance. The factors contributing significantly to SR, which accounted for 28.8% of the variance, were weight (P=0.004), age (P<0.001) and the BstUI RFLP (P=0.001). These data suggest that the COL5A1 BstUI RFLP is independently associated with lower limb ROM within the cohort investigated in this study. © 2009 John Wiley & Sons A/S.
Authors & Co-Authors
Collins, Malcolm R.
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
Mokone, Gaonyadiwe George
South Africa, Cape Town
University of Cape Town
September, Alison Victoria
South Africa, Cape Town
University of Cape Town
van der Merwe, Lize
South Africa, Tygerberg
South African Medical Research Council
South Africa, Bellville
University of the Western Cape
Schwellnus, MP Peter
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 76
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1111/j.1600-0838.2009.00915.x
ISSN:
09057188
e-ISSN:
16000838
Research Areas
Genetics And Genomics
Violence And Injury
Study Design
Cohort Study