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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Induction of Plasmodium falciparum-specific CD4
+
T cells and memory B cells in gabonese children vaccinated with RTS,S/AS01
E
and RTS,S/AS02
D
PLoS ONE, Volume 6, No. 4, Article e18559, Year 2011
Notification
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Description
The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01E and RTS,S/AS02D. Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2+ CD4+ T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01E and RTS,S/AS02D induced adaptive immune responses including antibodies, circulating memory B cells and CD4+ T cells directed against P. falciparum CS protein. Trial Registration: ClinicalTrials.gov NCT00307021. © 2011 Agnandji et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3073948/bin/pone.0018559.s001.doc
Authors & Co-Authors
Agnandji, Sélidji Todagbe M.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Fendel, Rolf
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Mestré, Michaël
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Janssens, Michel Etienne
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Vekemans, Johan
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Held, Jana
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gnansounou, Ferdinand
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Haertle, Sonja
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
von Glasenapp, Isabel
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Oyakhirome, Sunny
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Mewono, Ludovic
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Moris, Philippe J.
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Lievens, Marc J.J.
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Demoitié, Marie Ange
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Dubois, Patrice M.
Belgium, Brussels
Immunovacc Consulting
Villafana, Tonya L.
United States, Bethesda
Path Malaria Vaccine Initiative
Jongert, Erik
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Olivier, Aurélie C.
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Cohen, Joe D.
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Esen, Meral
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kremsner, Peter G.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Lell, Bertrand
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Mordmüller, Benjamin G.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 45
Authors: 23
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0018559
e-ISSN:
19326203
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study