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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Y chromosome lineage- and village-specific genes on chromosomes 1p22 and 6q27 control visceral leishmaniasis in Sudan
PLoS Genetics, Volume 3, No. 5, Year 2007
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Description
Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major susceptibility gene on Chromosome 22q12 in the Aringa ethnic group in Sudan. We now report a genome-wide scan using 69 families with 173 affected relatives from two villages occupied by the related Masalit ethnic group. A primary ten-centimorgan scan followed by refined mapping provided evidence for major loci at 1p22 (LOD score 5.65; nominal p=1.72×10-7; empirical p < 1×10-5; λS= 5.1) and 6q27 (LOD score 3.74; nominal p = 1.68 × 10-5; empirical p < 1 × 10-4; λS = 2.3) that were Y chromosome-lineage and village-specific. Neither village supported a visceral leishmaniasis susceptibility gene on 22q12. The results suggest strong lineage-specific genes due to founder effect and consanguinity in these recently immigrant populations. These chance events in ethnically uniform African populations provide a powerful resource in the search for genes and mechanisms that regulate this complex disease. © 2007 Miller et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1866354/bin/pgen.0030071.st001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC1866354/bin/pgen.0030071.sd001.doc
Authors & Co-Authors
Miller, Elinor Nancy
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Fadl, Manal
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Mohamed, H. S.
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Elzein, Abier M.
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Jamieson, Sarra Elisabeth
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Cordell, Heather Jane
United Kingdom, Cambridge
Cambridge Institute for Medical Research
United Kingdom, Newcastle
Newcastle University
Peacock, Christopher Sean
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Fakiola, Michaela
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Raju, Madhuri
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Khalil, Eltahir Awad Gasim
Sudan, Khartoum
Institute of Endemic Diseases Sudan
el-Hassan, Ahmed Mohamed A.
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Musa, Ahmed Mudawi
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Ibrahim, Muntaser Eltayeb
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Blackwell, Jenefer Mary
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Statistics
Citations: 74
Authors: 14
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pgen.0030071
e-ISSN:
15537404
Research Areas
Genetics And Genomics
Study Locations
Sudan