Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung
Journal of Clinical Investigation, Volume 131, No. 10, Year 2021
Notification
URL copied to clipboard!
Description
T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung, and is generally studied in humans using peripheral blood cells. Mounting evidence, however, indicates that tissue-resident memory T cells (Trms) are superior at controlling many pathogens, including Mycobacterium tuberculosis (M. tuberculosis), and can be quite different from those in circulation. Using freshly resected lung tissue, from individuals with active or previous TB, we identified distinct CD4+and CD8+ Trm-like clusters within TB-diseased lung tissue that were functional and enriched for IL-17–producing cells. M. tuberculosis–specific CD4+ T cells producing TNF-α, IL-2, and IL-17 were highly expanded in the lung compared with matched blood samples, in which IL-17+ cells were largely absent. Strikingly, the frequency of M. tuberculosis–specific lung T cells making IL-17, but not other cytokines, inversely correlated with the plasma IL-1β levels, suggesting a potential link with disease severity. Using a human granuloma model, we showed the addition of either exogenous IL-17 or IL-2 enhanced immune control of M. tuberculosis and was associated with increased NO production. Taken together, these data support an important role for M. tuberculosis–specific Trm-like, IL-17–producing cells in the immune control of M. tuberculosis in the human lung. © 2021, Ogongo et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8121523/bin/jci-131-142014-s066.pdf
Authors & Co-Authors
Ogongo, Paul
Unknown Affiliation
Tezera, Liku B.
Unknown Affiliation
Ardain, Amanda
Unknown Affiliation
Nhamoyebonde, Shepherd
Unknown Affiliation
Ramsuran, Duran
Unknown Affiliation
Singh, Alveera
Unknown Affiliation
Ng’oepe, Abigail T.
Unknown Affiliation
Karim, Farina
Unknown Affiliation
Naidoo, Taryn
Unknown Affiliation
Khan, Khadija Akbar
Unknown Affiliation
Dullabh, Kaylesh Jay
Unknown Affiliation
Fehlings, Michael
Unknown Affiliation
Lindestam Arlehamn, Cecilia S.
Unknown Affiliation
Sette, Alessandro D.
Unknown Affiliation
Behar, Samuel M.
Unknown Affiliation
Steyn, Adrie J.C.
Unknown Affiliation
Madansein, Rajhmun
Unknown Affiliation
Kløverpris, Henrik N.
Unknown Affiliation
Elkington, Paul
Unknown Affiliation
Leslie, Alasdair J.
Unknown Affiliation
Statistics
Citations: 40
Authors: 20
Identifiers
Doi:
10.1172/JCI142014
ISSN:
00219738
Research Areas
Infectious Diseases