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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparison of the diagnostic and prognostic values of B-type and atrial-type natriuretic peptides in acute heart failure
International Journal of Cardiology, Volume 168, No. 4, Year 2013
Notification
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Description
Background We compared diagnostic and prognostic properties of brain natruiretic peptide (BNP), proBNP, NT-proBNP and MR-pro-atrial natriuretic peptide (ANP) in patients admitted with shortness of breath (SOB). Methods All 4 NPs were measured in patients admitted to the emergency unit with SOB (in 2 centers) or acute heart failure (AHF) (1 FINN-AKVA cohort) and in a control population of stable chronic HF. Follow-up was 1 (2 centers) and 5 years (1 FINN-AKVA cohort). Area under the curve (AUC) was used to assess diagnostic properties. AUC, multivariate Cox regression, net reclassification improvement (NRI), and Kaplan-Meier analyses were used to assess mortality. Results We included 710 patients ("Biomarcoeurs" cohort n = 336; FINN-AKVA study, n = 306; stable chronic HF, n = 68). Pro-BNP was almost as powerful as BNP to diagnose AHF (AUC 0.953 vs 0.973 respectively, p = 0.003), NT-proBNP also performed well (0.922, p < 0.001 vs BNP). MR-proANP performed less well (0.901). AUC over time showed greater MR-proANP values over the first year. At 5 years, MR-proANP had the best prognostic value (AUC 0.668 vs 0.604 for BNP, p = 0.042). Kaplan Meier analysis confirmed better survival with MR-proANP ≤ 416.8 pmol/L at 5 years. NRI at 5 years was greater for MR-proANP (0.23, p < 0.05) than for proBNP, BNP or NTproBNP (p = NS). Conclusion Our study provides firm evidence that all NPs perform equally well for diagnostic purposes, and that MR-proANP has long term prognostic value in patients with acute heart failure. © 2013 Elsevier Ireland Ltd.
Authors & Co-Authors
Séronde, Marie France
France, Besancon
Hopital Jean Minjoz
France, Paris
Biomarqueurs Cardioneurovasculaires
Gayat, Étienne
France, Paris
Hôpital Lariboisiere Ap-hp
Logeart, Damien
France, Paris
Biomarqueurs Cardioneurovasculaires
France, Paris
Université Paris Cité
France, Paris
Hôpital Lariboisiere Ap-hp
Lassus, Johan P.E.
Finland, Helsinki
Helsinki University Hospital
Laribi, Said
France, Paris
Biomarqueurs Cardioneurovasculaires
France, Paris
Hôpital Lariboisiere Ap-hp
Boukef, Riadh
Tunisia, Monastir
Chu Fattouma-bourguiba
Sibellas, Franck
France, Lyon
Hopital Louis Pradel
Launay, Jean Marie
France, Paris
Biomarqueurs Cardioneurovasculaires
France, Paris
Hôpital Lariboisiere Ap-hp
Manivet, Philippe
France, Paris
Hôpital Lariboisiere Ap-hp
Sadoune, Malha
France, Paris
Biomarqueurs Cardioneurovasculaires
Nouira, Semir
Tunisia, Monastir
Chu Fattouma-bourguiba
Cohen-Solal, Alain
France, Paris
Biomarqueurs Cardioneurovasculaires
France, Paris
Université Paris Cité
France, Paris
Hôpital Lariboisiere Ap-hp
Mebazaa, Alexandre
France, Paris
Biomarqueurs Cardioneurovasculaires
France, Paris
Hôpital Lariboisiere Ap-hp
France, Paris
Université Paris Cité
Statistics
Citations: 13
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1016/j.ijcard.2013.04.164
ISSN:
01675273
e-ISSN:
18741754
Study Design
Cross Sectional Study
Cohort Study