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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
RelA and RelB cross-talk and function in Epstein-Barr virus transformed B cells
Leukemia, Volume 28, No. 4, Year 2014
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Description
In this study, we determined the respective roles of RelA and RelB NF-κB subunits in Epstein-Barr virus (EBV)-transformed B cells. Using different EBV-immortalized B-cell models, we showed that only RelA activation increased both survival and cell growth. RelB activity was induced secondarily to RelA activation and repressed RelA DNA binding by trapping the p50 subunit. Reciprocally, RelA activation repressed RelB activity by increasing expression of its inhibitor p100. To search for such reciprocal inhibition at the transcriptional level, we studied gene expression profiles of our RelA and RelB regulatable cellular models. Ten RelA-induced genes and one RelB-regulated gene, ARNTL2, were repressed by RelB and RelA, respectively. Apart from this gene, RelB signature was included in that of RelA Functional groups of RelA-regulated genes were for control of energy metabolism, genetic instability, protection against apoptosis, cell cycle and immune response. Additional functions coregulated by RelA and/or RelB were autophagy and plasma cell differentiation. Altogether, these results demonstrate a cross-inhibition between RelA and RelB and suggest that, in fine, RelB was subordinated to RelA. In the view of future drug development, RelA appeared to be pivotal in both classical and alternative activation pathways, at least in EBV-transformed B cells. © 2014 Macmillan Publishers Limited.
Authors & Co-Authors
Chanut, A.
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
Duguet, F.
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
Marfak, Abdelghafour
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
Morocco, Agdal Rabat
Ifcs Institut de Formation Aux Carriè Res de Santé
David, A.
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
Petit, B.
France, Limoges
Hopital Dupuytren
Parrens, Marie
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Durand-Panteix, S.
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
Boulin-Deveza, M.
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
Gachard, N.
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
Youlyouz-Marfak, Ibtissam
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
B́ordessoule, Dominique
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
France, Limoges
Hopital Dupuytren
Feuillard, Jean
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
Faumont, Nathalie
France, Limoges
Contrôle de la Réponse Immune b et Lymphoproliférations
Statistics
Citations: 17
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1038/leu.2013.274
ISSN:
08876924
e-ISSN:
14765551
Research Areas
Cancer
Genetics And Genomics