Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria
Emerging Infectious Diseases, Volume 19, No. 5, Year 2013
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Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.