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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Combining autosomal and Y-chromosomal short tandem repeat data in paternity testing with male child: Methods and application
Journal of Forensic Sciences, Volume 52, No. 5, Year 2007
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Description
Paternity testing is being increasingly requested with the aim of challenging presumptive fatherhood. The ability to establish the biological father is usually based on the genotyping of autosomal short tandem repeat (STR) in alleged father, mother and child, but the use of Y-chromosomal STR has gained interest in the last few years. In this work, we propose a new probabilistic approach that combines autosomal and Y-chromosomal STR data in paternity testing with father/son pairs taking into account mutation events. We also suggest a new two-stage approach where we first type Y-STRs and possibly autosomal STR for the putative father and son, conditional on Y-STR results. We applied this approach to 22 cases. Our results show that Y-STRs can identify nonpaternity cases with high accuracy but need to be validated with autosomal STR to establish paternity. Moreover, the two-stage approach is less costly than the standard approach and is very useful in motherless cases. © 2007 American Academy of Forensic Sciences.
Authors & Co-Authors
Ayadi, Imen
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Mahfoudh, Nadia
Tunisia, Sfax
Chu Hedi-chaker
Makni, Hafedh
Tunisia, Sfax
Chu Hedi-chaker
Ammar-Keskes, Leila
Tunisia, Sfax
Faculty of Medicine of Sfax
REBAI, AHMED
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Statistics
Citations: 18
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1111/j.1556-4029.2007.00513.x
ISSN:
00221198
e-ISSN:
15564029
Research Areas
Cancer
Maternal And Child Health
Participants Gender
Male