Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients
Journal of Infection in Developing Countries, Volume 6, No. 1, Year 2012
Notification
URL copied to clipboard!
Description
Introduction: Among opportunistic pathogens associated with acquired immunodeficiency syndrome (AIDS), Mycobacterium tuberculosis is distinguished by its relative virulence and potential for person-to-person transmission. Oxidative stress is associated with TB infection with a high level in patients with HIV-TB co-infection. However, the comparative level of oxidative stress in HIV patients on highly active anti-retroviral therapy (HAART) and naïve (untreated) HIV patients is not clear. Methodology: This study is aimed to determine the level of oxidative stress and haematological parameters in HIV patients (naïve), HIV patients undergoing HAART, and HIV-TB co-infected patients. In total, 100 consenting subjects were recruited from the AIDS Prevention Iniative in Nigeria (APIN) Clinic. For controls, normal male healthy volunteers were recruited from the blood donor clinic and females from the APIN clinic staff members, both of the Lagos University Teaching Hospital. Measurements of antioxidant enzyme activity and lipid peroxidation were performed according to standard procedures. Haematological parameters were determined using a fully automated hematology analyzer. Results: Red blood cells significantly decreased (P≤0.001) in all patients when compared with control subjects. The lipid peroxidation (MDA) was significantly high (P≤0.05) in naive patients when compared to HIV patients on HAART. The decrease in the levels of GSH in both naive and HIV-TB co-infected patients (P≤0.001) and HIV patients on HAART (P<0.05) were significant when compared to control patients. Conclusion: There is lower antioxidant level and higher MDA in naive and HIV-TB co-infected patients as compared to HIV patients on HAART and the seronegative patients. © 2012 Awodele et al.
Authors & Co-Authors
Awodele, Olufunsho E.
Nigeria, Lagos
University of Lagos
Olayemi, Sunday Oluwafemi
Nigeria, Lagos
University of Lagos
Nwite, Joseph A.
Nigeria, Lagos
University of Lagos
Adeyemo, T. A.
Nigeria, Lagos
University of Lagos
Statistics
Citations: 65
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.3855/jidc.1906
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Nigeria
Participants Gender
Male
Female