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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association of IRF5 gene polymorphisms with rheumatoid arthritis in a Tunisian population
Scandinavian Journal of Rheumatology, Volume 37, No. 6, Year 2008
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Description
Objective: A strong genetic association of rheumatoid arthritis (RA) with the interferon regulatory factor 5 (IRF5) gene has been described previously in a Swedish population, although this result was not confirmed in a French population. We undertook an association study between IRF5 and the RA phenotype, as well as a study with serological markers of RA, in a Tunisian population. Methods: A single-nucleotide polymorphism (SNP; rs2004640) was genotyped using a Taqman 5' allelic discrimination assay on an ABI 7500 real-time polymerase chain reaction (PCR) instrument in 140 RA patients and 185 controls. Rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA) were determined by enzyme-linked immunosorbent assay (ELISA). Association was assessed based on the χ2 test and odds ratios (ORs) with 95% confidence intervals (CIs). Results: The frequency of the TT genotype of the IRF5 SNP rs2004640 differed significantly between patients and controls (p=0.01). This difference was greater when a subgroup of patients with another 'autoimmune' disorder was considered (p=0.007). A weak but significant association was also found in a subgroup of patients who were positive for ACPA (p=0.04) or erosion (p=0.01). Conclusions: Our results indicate that the TT genotype of the IRF5 (rs2004640) dimorphism is associated with RA in a Tunisian population. © 2008 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.
Authors & Co-Authors
Maalej, Abdellatif
Tunisia, Sfax
Faculty of Medicine of Sfax
Ben Hamad, Mariem
Tunisia, Sfax
Faculty of Medicine of Sfax
REBAI, AHMED
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Teixeira, V. H.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Portugal, Coimbra
University of Coimbra, Center for Neuroscience and Cell Biology
Bahloul, Zouhir
Tunisia, Sfax
Chu Hedi-chaker
Marzouk, Sameh
Tunisia, Sfax
Chu Hedi-chaker
Farid, Nadir R.
United Kingdom, Watford
Osancor Biotech Inc.
Ayadi, Hammadi
Tunisia, Sfax
Faculty of Medicine of Sfax
Cornélis, François B.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Petit-Teixeira, Élisabeth
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Statistics
Citations: 23
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1080/03009740802256327
ISSN:
03009742
e-ISSN:
15027732
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study