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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Dynamics of the cytokine response to Mycobacterium ulcerans during antibiotic treatment for M. ulcerans disease (Buruli ulcer) in humans
Clinical and Vaccine Immunology, Volume 16, No. 1, Year 2009
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Description
We have studied the evolution of the gamma interferon (IFN-γ) and interleukin 10 (IL-10) responses after Mycobacterium ulcerans sonicate stimulation of whole blood from patients with early M. ulcerans lesions during treatment with rifampin and streptomycin for 8 weeks. Among the 26 patients, secretion of IFN-γ increased during treatment, with a significant increase at 4 weeks and a further increase after 8 weeks overall. The increase was more rapid in patients with large or ulcerative lesions, becoming significant by 4 weeks. For small lesions, there was only a minor increase, which did not reach significance. There was no significant change in the median IL-10 response during antibiotic therapy, and there was no inverse correlation between IFN-γ and IL-10 responses. These results demonstrate that an IFN-γ secretory response to M. ulcerans developed, independently of IL-10 secretion, in patients whose M. ulcerans disease healed during antibiotic therapy. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Sarfo, Fred Stephen
Unknown Affiliation
Phillips, Richard Odame
Unknown Affiliation
Ampadu, Edwin O.
Unknown Affiliation
Sarpong, Frederick
Unknown Affiliation
Adentwe, E.
Unknown Affiliation
Wansbrough-Jones, Mark H.
Unknown Affiliation
Statistics
Citations: 31
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1128/CVI.00235-08
ISSN:
15566811
e-ISSN:
1556679X