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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Impact of peritoneal cytology on survival of endometrial cancer patients treated with surgery and radiotherapy
British Journal of Cancer, Volume 89, No. 11, Year 2003
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Description
Stage IIIA endometrial cancer includes patients with serosal or adnexal invasion and patients with positive peritoneal cytology only. In this study, we assessed the impact of peritoneal cytology on endometrial cancer survival. All endometrial cancer patients receiving surgery and radiotherapy at the Geneva University Hospitals between 1980 and 1993 were included. Stage IIIA cancers were categorised into 'cytological' stage IIIA (only positive peritoneal cytology) and 'histological' stage IIIA (serosal or adnexal infiltration). Survival rates were analysed by Kaplan-Meier method and compared using log-rank test. The prognostic importance of peritoneal cytology was analysed by multivariate regression analysis. This study included 170 endometrial cancers (112 stage 1, 17 cytological stage IIIA, 18 histological stage IIIA, 9 stage IIIB +). Disease-specific survival of cytological stage IIIA was not different from stage 1 (94 vs 88% respectively, P = 0.5) but better than histological stage IIIA (94 vs 51% respectively, P < 0.01). Histological stage IIIA patients were at increased risk to die from cancer compared to stage 1 patients (HR 2.7, 95% Cl 1.0-7.7), while cytological stage IIIA patients were not (HR 0.3, 95% Cl 0.3-2.0). Cytological stage IIIA endometrial cancer has similar prognosis as stage 1 and better prognosis than histological stage IIIA. Additional research, definitively separating stage and cytology is warranted. © 2003 Cancer Research UK.
Authors & Co-Authors
Tebeu, Pierre Marie
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Cameroon
Yaounde University Hospitals
Popowski, G. Y.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Verkooijen, Helena Marieke
Switzerland, Geneva
Registre Genevois Des Tumeurs
Casals, J.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Lüdicke, Franck
Switzerland, Geneva
Université de Genève
Zeciri, G.
Switzerland, Geneva
Université de Genève
Usel, Massimo
Switzerland, Geneva
Registre Genevois Des Tumeurs
Bouchardy, Christine
Switzerland, Geneva
Registre Genevois Des Tumeurs
Major, Attila Louis
Switzerland, Geneva
Université de Genève
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Statistics
Citations: 30
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1038/sj.bjc.6601446
Research Areas
Cancer
Health System And Policy
Study Approach
Quantitative