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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pharmacokinetics and absolute oral bioavailability of an 800-mg oral dose of telithromycin in healthy young and elderly volunteers
Chemotherapy, Volume 48, No. 4-5, Year 2002
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Description
Background: This two-way, randomized, single-dose, crossover study determined the pharmacokinetics and absolute oral bioavailability of telithromycin in young and elderly healthy subjects. Methods: Twelve young (18-40 years) and 12 elderly (>65 years and ≤85 years) subjects received a single 800-mg oral dose of telithromycin or an intravenous infusion of 400 mg (young subjects) or 480 mg (elderly subjects) of telithromycin over 2.5 h in two treatment periods, separated by a 1-week washout period. The plasma concentrations and pharmacokinetic parameters of telithromycin and its major metabolite, RU 76363, were determined. Absolute oral bioavailability was calculated using the area under the plasma concentration-time curve (AUC) from zero hours to infinity. Results: The absolute oral bioavailability of telithromycin was 57% in both young and elderly subjects. The AUC for the metabolite was lower after intravenous infusion of telithromycin, indicating first-pass loss following oral administration. Telithromycin was well tolerated in both groups of subjects. Conclusions: Telithromycin has an absolute oral bioavailability of 57% in young and elderly subjects and is well tolerated. Copyright © 2002 S. Karger AG, Basel.
Authors & Co-Authors
Perret, C.
France, Gentilly
Sanofi S.a.
Lenfant, Bernard
France, Gentilly
Sanofi S.a.
Weinling, E.
France, Gentilly
Sanofi S.a.
Wessels, D. H.
South Africa, Bloemfontein
Farmovs Research Centre
Scholtz, H. E.
South Africa, Bloemfontein
Farmovs Research Centre
Montay, Guy
France, Gentilly
Sanofi S.a.
Sultan, Eric
France, Gentilly
Sanofi S.a.
Statistics
Citations: 53
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1159/000066766
ISSN:
00093157
Research Areas
Health System And Policy