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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Nonpathogenic simian immunodeficiency virus infection of sooty mangabeys is not associated with high levels of autologous neutralizing antibodies
Journal of Virology, Volume 84, No. 12, Year 2010
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Description
Simian immunodeficiency virus (SIV) infection of natural-host species, such as sooty mangabeys (SMs), is characterized by a high level of viral replication and a low level of generalized immune activation, despite evidence of an adaptive immune response. Here the ability of SIV-infected SMs to mount neutralizing antibodies (Nab) against autologous virus was compared to that of human immunodeficiency virus type 1 (HIV-1) subtype C-infected subjects. While high levels of Nab were observed in HIV-1 infection, samples obtained at comparable time points from SM exhibited relatively low titers of autologous Nab. Nevertheless, SM plasma with higher Nab titers also contained elevated peripheral CD4+ T-cell levels, suggesting a potential immunologic benefit for SMs. These data indicate that AIDS resistance in these primates is not due to high Nab titers and raise the possibility that low levels of Nab might be an inherent feature of natural-host SIV infections. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Li, Bing
United States, Atlanta
Emory University
Stefano-Cole, Kelly
United States, Pittsburgh
University of Pittsburgh School of Medicine
Kuhrt, David M.
United States, Pittsburgh
University of Pittsburgh School of Medicine
Gordon, Shari N.
United States, Philadelphia
University of Pennsylvania
United States, Bethesda
National Institutes of Health Nih
Else, James G.
United States, Atlanta
Emory University
Mulenga, Joseph
Zambia, Lusaka
Zambia Blood Transfusion Service
Allen, Susan A.
United States, Atlanta
Emory University
Sodora, Donald L.
United States, Seattle
Seattle Biomedical Research Institute
Silvestri, Guido Do
United States, Atlanta
Emory University
United States, Philadelphia
University of Pennsylvania
Derdeyn, Cynthia A.
United States, Atlanta
Emory University
Statistics
Citations: 40
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1128/JVI.00295-10
ISSN:
0022538X
Research Areas
Infectious Diseases