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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Revising the upper limit of normal for levels of serum alanine aminotransferase in a middle eastern population with normal liver histology
Digestive Diseases and Sciences, Volume 58, No. 8, Year 2013
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Description
Background: Recently, the upper limits of normal (ULN) for alanine-aminotransferase (ALT) has been recommended to be lowered to ≤30 U/l in men and ≤19 U/l in women. Aim: To evaluate the ALT concentrations in a healthy Middle Eastern population with biopsy-proven normal liver tissue. Methods: ALT values were calculated from 175 consecutive Saudi potential living liver donors who underwent a liver biopsy as part of a stepwise pretransplant workup. Results: The mean age of the 110 potential donors with normal liver histology was 27 ± 6.2 years for men and 38.6 ± 7.1 years for women. The mean body mass index (BMI) levels were 23.0 ± 3.5 kg/m 2 for men and 24.7 ± 3.25 kg/m2 for women, and the ALT levels were higher in male patients (22.6 ± 9 vs. 16.4 U/l ± 8, p value = 0.003). Multivariate linear regression showed that BMI and sex were independent variables that were positively associated with the levels of ALT (p < 0.0001). Moreover, when we analyzed donors according to the Prati criteria, 63 (36.0 %) of the individuals were classified into this subgroup. The mean ALT concentration was 12.9 U/l ± 4.5 in women and 19.7 U/l ± 6.9 in men, and these values were significantly lower than those obtained from subjects who did not fit the Prati criteria (19.4 U/l ± 1.8, p = 0.04 for women and 29.0 U/l ± 12.1, p = <0.0001 for men). Thus, we calculated healthy ALT values of 33 IU/l for men and 22 IU/l for women. Conclusions: The ULN for ALT levels in Middle Eastern populations should be lowered, including separate values for males and females. Furthermore, metabolic parameters were shown to have a significant effect on ALT levels. © 2013 Springer Science+Business Media New York.
Authors & Co-Authors
Al-Hamoudi, Waleed Khalid
Saudi Arabia, Riyadh
College of Medicine
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Ali, Safiyya Mohamed
Saudi Arabia, Riyadh
College of Medicine
Hegab, Bassem Soliman
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Egypt, Shibin el Kom
Menoufia University
Elsiesy, Hussien A.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Hashim, Almoutaz H.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-sofayan, Mohammed S.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Khalaf, Hatem Ali
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Bahili, Hamad Mohd
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Masri, Nasser M.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Sebayel, Mohammed Ibrahim M.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Bröering, Dieter Clemens
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Abdo, Ayman Assad
Saudi Arabia, Riyadh
College of Medicine
Alqahtani, Saleh A.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Abaalkhail, Faisal Abdulrahman
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 20
Authors: 14
Affiliations: 3
Identifiers
Doi:
10.1007/s10620-013-2659-0
ISSN:
01632116
e-ISSN:
15732568
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Male
Female