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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Potential neuroimmunological targets in the treatment of anxiety disorders
Modern Trends in Pharmacopsychiatry, Volume 29, Year 2013
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Description
In the translation of psychoneuroimmunology research into clinical practice, one critical step is to identify biomarkers for improved diagnosis and targeting of interventions. Inflammatory markers deserve special attention due to their crucial role linking various health conditions and disorders. In this chapter, we discuss the pivotal roles of cytokines in signalling to the brain and leading to behavioural changes. This is followed by a review of recent research findings into neuroimmunology of depression, and immunomodulating effects of antidepressants. The rest of the chapter focuses on neuroinflammatory hypothesis in anxiety disorders, and provides an overview of current research evidence on inflammatory responses in anxious state and anxiety disorders. Research suggestions are recommended, including study design, risk factors, medication effects, and measurement strategies. Clinical and pharmacotherapeutic implications and future research directions are also discussed in the final section. Copyright © 2013 S. Karger AG, Basel.
Authors & Co-Authors
Hou, Ruihua
United Kingdom, Southampton
University of Southampton
Tang, Zhen
China, Suzhou
Suzhou University
Baldwin, David S.
United Kingdom, Southampton
University of Southampton
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 6
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1159/000351965
ISSN:
16622685
Research Areas
Mental Health
Substance Abuse