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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Detection of hepatitis E virus of genotype 3 in a farm pig in Kinshasa (Democratic Republic of the Congo)
Infection, Genetics and Evolution, Volume 10, No. 1, Year 2010
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Description
Autochthonous hepatitis E is an emerging disease in industrialized countries where a growing body of data indicates that pigs represent a reservoir for hepatitis E virus (HEV) of genotype 3 or 4. In Africa, only HEV genotypes 1 and 2 have been identified in hepatitis E outbreaks as well as in sporadic cases. We aimed to investigate whether commercial pigs in sub-Saharan Africa might represent an HEV reservoir using molecular assays. Faecal samples from 40 pigs of the Pietrain race housed in a farm in Kinshasa (Democratic Republic of the Congo) were tested using in-house real-time reverse transcription (RT)-PCR and sequencing assays. HEV RNA was detected in faeces of one (2.5%) pig, and the HEV sequence obtained from this pig was classified genotype 3c, and was genetically related to human HEV sequences from France (89-92% nucleotide similarity) and pig HEV sequences from The Netherlands (88-91% nucleotide similarity). Epidemiological investigations revealed that Kinshasa farm pigs tested in the present study are descendants of pigs imported from Belgium in 2002, suggesting that pig HEV genotype 3c recovered in our study may have been imported from Belgium to Democratic Republic of the Congo. Our findings, although needing to be confirmed in further studies, also suggest that pigs in sub-Saharan Africa may be an HEV reservoir. © 2009 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Kaba, Mamadou
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
France, Marseille
Pôle Des Maladies Infectieuses et Tropicales Clinique et Biologique
Colson, Philippe
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
France, Marseille
Pôle Des Maladies Infectieuses et Tropicales Clinique et Biologique
Musongela, Jean Pierre
Democratic Republic Congo, Uvira
Ministère de la Santé Publique
Tshilolo, Léon Muepu
Congo, Kinshasa
Centre Hospitalier Monkole
Davoust, Bernard
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
France, Toulon
Direction Régionale du Service de Santé Des Armées de Toulon
Statistics
Citations: 37
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1016/j.meegid.2009.09.011
ISSN:
15671348
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Congo