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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Human papillomavirus infection and increased risk of HIV acquisition. A systematic review and meta-analysis
AIDS, Volume 26, No. 17, Year 2012
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Description
OBJECTIVES: Human papillomavirus (HPV), one of the commonest sexually transmitted infections, may be a cofactor in HIV acquisition. We systematically reviewed the evidence for an association of HPV infection with HIV acquisition in women, heterosexual men and men who have sex with men (MSM). DESIGN: Systematic review and meta-analysis. METHODS: Studies meeting inclusion criteria in Pubmed, Embase and conference abstracts up to 29 July 2011 were identified. Random effects meta-analyses were performed to calculate summary hazard ratios (HR). Publication bias and statistical heterogeneity were evaluated and population attributable fractions (PAFs) calculated. RESULTS: Eight articles were included, with previously unpublished data from five authors. Seven studies found an association between prevalent HPV and HIV acquisition. Risk of HIV acquisition in women doubled with prevalent HPV infection with any genotype [HR=2.06 (95% CI=1.44-2.94), I=0%], although adjustment for confounders was often inadequate. The effect was similar for high-risk [HR=1.99 (95% CI=1.54-2.56), I=8.4%] and low-risk [HR=2.01 (95% CI=1.27-3.20), I=0%] HPV genotypes with weak evidence of publication bias (P=0.06). Two studies in men were identified: both showed an association between HPV infection and HIV acquisition. Unpublished data from one of two studies in women indicated an association between genotypes targeted by HPV vaccines and HIV acquisition. PAFs for HIV attributable to infection with any HPV genotype ranged between 21 and 37%. CONCLUSION: If further studies validate the association between HPV infection and HIV acquisition, HPV vaccines may reduce HIV incidence in high HPV prevalence populations, in addition to preventing cervical cancer. HIV surveillance studies during implementation of HPV vaccine programmes are warranted. © 2012 Wolters Kluwer Health / Lippincott Williams & Wilkins.
Authors & Co-Authors
Houlihan, Catherine F.
Unknown Affiliation
Larke, Natasha L.
Unknown Affiliation
Watson – Jones, Deborah
Unknown Affiliation
Smith-McCune, Karen K.
Unknown Affiliation
Shiboski, Stephen C.
Unknown Affiliation
Gravitt, Patti E.
Unknown Affiliation
Smith, Jennifer Susan
Unknown Affiliation
Kuhn, Louise
Unknown Affiliation
Wang, Chunhui
Unknown Affiliation
Hayes, Richard John
Unknown Affiliation
Statistics
Citations: 155
Authors: 10
Affiliations: 10
Identifiers
Doi:
10.1097/QAD.0b013e328358d908
e-ISSN:
14735571
Research Areas
Cancer
Environmental
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review
Participants Gender
Male
Female