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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The Arabian cradle: Mitochondrial relicts of the first steps along the Southern route out of Africa
American Journal of Human Genetics, Volume 90, No. 2, Year 2012
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Description
A major unanswered question regarding the dispersal of modern humans around the world concerns the geographical site of the first human steps outside of Africa. The "southern coastal route" model predicts that the early stages of the dispersal took place when people crossed the Red Sea to southern Arabia, but genetic evidence has hitherto been tenuous. We have addressed this question by analyzing the three minor west-Eurasian haplogroups, N1, N2, and X. These lineages branch directly from the first non-African founder node, the root of haplogroup N, and coalesce to the time of the first successful movement of modern humans out of Africa, ∼60 thousand years (ka) ago. We sequenced complete mtDNA genomes from 85 Southwest Asian samples carrying these haplogroups and compared them with a database of 300 European examples. The results show that these minor haplogroups have a relict distribution that suggests an ancient ancestry within the Arabian Peninsula, and they most likely spread from the Gulf Oasis region toward the Near East and Europe during the pluvial period 55-24 ka ago. This pattern suggests that Arabia was indeed the first staging post in the spread of modern humans around the world. © 2012 The American Society of Human Genetics.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3276663/bin/mmc1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3276663/bin/mmc2.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3276663/bin/mmc3.zip
Authors & Co-Authors
Fernandes, Verónica
Portugal, Porto
Universidade do Porto
United Kingdom, Leeds
University of Leeds
Alshamali, Farida H.
United Arab Emirates, Dubai
Dubai Egovernment, Dubai Police
Alves, Marco G.
Portugal, Porto
Universidade do Porto
Costa, Marta Daniela
Portugal, Porto
Universidade do Porto
United Kingdom, Leeds
University of Leeds
Pereira, Joana Barbosa
Portugal, Porto
Universidade do Porto
United Kingdom, Leeds
University of Leeds
Silva, Nuno Miguel
Portugal, Porto
Universidade do Porto
Cherni, L.
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Harich, Nourdin
Morocco, El Jadida
Faculté Des Sciences D'el Jadida
Černý, Viktor
Czech Republic, Prague
Charles University
France, Paris
Institute for Political Studies
Soares, Pedro A.
Portugal, Porto
Universidade do Porto
Richards, Martin B.
United Kingdom, Leeds
University of Leeds
United Kingdom, Huddersfield
University of Huddersfield
Pereira, Luísa
Portugal, Porto
Universidade do Porto
Portugal, Porto
Faculdade de Medicina da Universidade do Porto Fmup
Statistics
Citations: 117
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1016/j.ajhg.2011.12.010
ISSN:
00029297
e-ISSN:
15376605
Research Areas
Genetics And Genomics