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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis, labelling and biological characteristics of derivatives of mercaptoacetyltriglycine with two amide functions
Journal of Labelled Compounds and Radiopharmaceuticals, Volume 45, No. 2, Year 2002
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Description
Eight novel derivatives of MAG3, containing in their structure two instead of three amide functions, have been synthesized and evaluated. The synthesized ligands were labelled with 99mTc by exchange labelling at 100°C and/or by a direct labelling method at room temperature. After labelling with 99mTc, the reaction mixtures were analyzed by radio-HPLC. Biological evaluation of different 99mTc-diamide complexes in mice and a baboon indicated that substitution in one amide function of MAG3 structure greatly influences the renal handling of these compounds. It was found that the diamide derivatives containing at least one inverted amide exhibit biological behavior comparable to that of 99mTc-MAG3. Copyright © 2002 John Wiley & Sons, Ltd.
Authors & Co-Authors
Okarvi, Subhani M.
Belgium, Leuven
Ku Leuven
Verbeke, K.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Adriaens, Paul J.
Belgium, Leuven
Ku Leuven
Verbruggen, Alfons Michel
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 6
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1002/jlcr.538
ISSN:
03624803