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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic polymorphisms of the bovine Fatty acid binding protein 4 gene are significantly associated with marbling and carcass weight in Hanwoo (Korean Cattle)
Animal Genetics, Volume 41, No. 4, Year 2010
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Description
The objective of this study was to investigate an association between polymorphisms in the FABP4 gene and phenotypic variation for marbling and carcass weight (CWT) in a population of Hanwoo steers. We re-sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism. Of these 16 SNPs, three SNPs [g.2774G>C (intron I), g.3473A>T (intron II) and g.3631G>A (exon III, creating a p.Met >Val amino acid substitution)] were genotyped in 583 steers to assess their association with carcass traits. The g.3473A allele showed a significant increasing effect on CWT (P = 0.01) and the g.3631G allele was associated with higher marbling score (P = 0.006). One haplotype of these three SNPs (CAG) was significantly associated with CWT (P = 0.02) and marbling score (P = 0.05) and could potentially be of value for marker assisted selection in Hanwoo cattle. The CAG haplotype effect for CWT was larger (11.14 ± 5.03 kg) than the largest single locus effect of g.3473A>T (5.01 ± 2.2 kg). © 2010 Stichting International Foundation for Animal Genetics.
Authors & Co-Authors
Lee, Seunghwan
South Korea, Jeonju
Rural Development Administration
Australia, Armidale
University of new England Australia
van der Werf, Julius H.Julius
Australia, Armidale
University of new England Australia
Lee, Sang-hong
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Oh, Sung-jong
South Korea, Jeonju
Rural Development Administration
Gibson, J. P.
Australia, Armidale
University of new England Australia
Thompson, John M.
Australia, Armidale
University of new England Australia
Statistics
Citations: 32
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-2052.2010.02024.x
ISSN:
13652052
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study