Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Predominant previous polarity as an outcome predictor in a controlled treatment trial for depression in bipolar I disorder patients
Journal of Affective Disorders, Volume 119, No. 1-3, Year 2009
Notification
URL copied to clipboard!
Description
Introduction: We hypothesized that predominant episode-polarity would predict response to treatment of depressive episodes in bipolar I disorder (BPD) patients with treatment in a placebo-controlled trial, in the sense that patients with manic predominant polarity (PM) would respond better than patients with depressive predominant polarity (PD). Method: This post-hoc analysis of a published trial examined outcomes of 788 depressed (MADRS score ≥ 20) adult BPD patients with baseline and follow-up assessments, according to their predominant polarity based on previous recurrences of mania-hypomania vs. depression in ≥ 2:1 excess. Patients (total = 833) were randomized to an 8-week trial of treatment with placebo (n = 377), olanzapine (5-20 mg/day; n = 370), or olanzapine/fluoxetine combination (OFC; 6/25, 6/50, or 12/50 mg/day; n = 86). Treatment response was based on improvement in Clinical Global Impression of depression severity (CGI-D). We analyzed for associations of this outcome with predominant lifetime illness-polarity, based on retrospective SCID-based assessment of individual clinical history. Results: Predominant polarity could be demonstrated in 367/788 patients (46.6%), showing a 2.7-fold excess of predominant depressive over manic past-illnesses (34.1%/12.4%), with similar distribution by sex and among treatment-arms. Moreover, based on least-square change in CGI-D severity (based on a mixed model of repeated measures [MMRM]), predominant polarity has different impact in the treatment outcome for each gender. Men with predominantly manic polarity had statistically significant better improvement than men with predominantly depressive polarity. Such difference was not observed in the female population. Other outcome measures yielded similar conclusions. Conclusions: Predominant previous depressive > manic episodes selectively yielded poorer responses of BPD to treatment for acute BP depression, particularly in men. © 2009 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Vieta, Eduard
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
United States, Boston
Harvard Medical School
Berk, Michael
Australia, Melbourne
The Florey
Colom, Francesc Victoriano
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Tohen, Mauricio F.
United States, Boston
Harvard Medical School
United States, Indianapolis
Eli Lilly and Company
Statistics
Citations: 59
Authors: 4
Affiliations: 5
Identifiers
Doi:
10.1016/j.jad.2009.02.028
ISSN:
01650327
Research Areas
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female