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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prophylactic ampicillin versus cefazolin for the prevention of post-cesarean infectious morbidity in Rwanda
International Journal of Gynecology and Obstetrics, Volume 124, No. 3, Year 2014
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Description
Objective: To evaluate the efficacy of ampicillin versus cefazolin as prophylactic antibiotics prior to cesarean delivery in Rwanda. Methods: In a prospective, randomized, open-label, single-site study conducted between March and May 2012, the effects of prophylactic ampicillin versus cefazolin were compared among women undergoing cesarean delivery at the Centre Hospitalier Universitaire de Kigali, Rwanda. Postoperatively, participants were evaluated daily for infectious morbidity while in the hospital. Follow-up was done by phone and by appointment at the hospital within 2 weeks of delivery. Results: During the study period, there were 578 total deliveries and 234 cesarean deliveries (40.4%). Overall, 132 women were enrolled in the study and randomized to receive either ampicillin (n = 66) or cefazolin (n = 66). No women were lost to follow-up. The overall infection rate was 15.9% (21/132). The infection rate in the ampicillin group and the cefazolin group was 25.8% (17/66) and 6.1% (4/66), respectively. Conclusion: Implementing a universal protocol in Rwanda of prophylactic cefazolin prior to cesarean delivery might reduce postoperative febrile morbidity, use of postoperative antibiotics, and number of postoperative days in hospital. © 2013 International Federation of Gynecology and Obstetrics.
Authors & Co-Authors
Mivumbi, Victor N.
Rwanda, Butare
University of Rwanda
Rwanda, Kigali
Centre Hospitalier Universitaire de Kigali
Little, Sarah E.
United States, Boston
Harvard Medical School
United States, Boston
Brigham and Women's/faulkner Hospitals
Rulisa, Stephen R.
Rwanda, Butare
University of Rwanda
Rwanda, Kigali
Centre Hospitalier Universitaire de Kigali
Greenberg, James A.
United States, Boston
Harvard Medical School
United States, Boston
Brigham and Women's/faulkner Hospitals
Statistics
Citations: 26
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1016/j.ijgo.2013.09.017
ISSN:
00207292
e-ISSN:
18793479
Research Areas
Health System And Policy
Study Design
Cohort Study
Study Locations
Rwanda
Participants Gender
Female