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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Treatment of Multisystem Inflammatory Syndrome in Children
New England Journal of Medicine, Volume 385, No. 1, Year 2021
Notification
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Description
BACKGROUND Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS We performed an international observational cohort study of clinical and outcome data regarding suspected MIS-C that had been uploaded by physicians onto a Web-based database. We used inverse-probability weighting and generalized linear models to evaluate intravenous immune globulin (IVIG) as a reference, as compared with IVIG plus glucocorticoids and glucocorticoids alone. There were two primary outcomes: the first was a composite of inotropic support or mechanical ventilation by day 2 or later or death; the second was a reduction in disease severity on an ordinal scale by day 2. Secondary outcomes included treatment escalation and the time until a reduction in organ failure and inflammation. RESULTS Data were available regarding the course of treatment for 614 children from 32 countries from June 2020 through February 2021; 490 met the World Health Organization criteria for MIS-C. Of the 614 children with suspected MIS-C, 246 received primary treatment with IVIG alone, 208 with IVIG plus glucocorticoids, and 99 with glucocorticoids alone; 22 children received other treatment combinations, including biologic agents, and 39 received no immunomodulatory therapy. Receipt of inotropic or ventilatory support or death occurred in 56 patients who received IVIG plus glucocorticoids (adjusted odds ratio for the comparison with IVIG alone, 0.77; 95% confidence interval [CI], 0.33 to 1.82) and in 17 patients who received glucocorticoids alone (adjusted odds ratio, 0.54; 95% CI, 0.22 to 1.33). The adjusted odds ratios for a reduction in disease severity were similar in the two groups, as compared with IVIG alone (0.90 for IVIG plus glucocorticoids and 0.93 for glucocorticoids alone). The time until a reduction in disease severity was similar in the three groups. CONCLUSIONS We found no evidence that recovery from MIS-C differed after primary treatment with IVIG alone, IVIG plus glucocorticoids, or glucocorticoids alone, although significant differences may emerge as more data accrue. Copyright © 2021 Massachusetts Medical Society.
Authors & Co-Authors
McArdle, Andrew J.
United Kingdom
Section of Pediatric Infectious Disease
Vito, Ortensia
United Kingdom
Section of Pediatric Infectious Disease
Patel, Harsita
United Kingdom
Section of Pediatric Infectious Disease
Seaby, Eleanor G.
United Kingdom
Section of Pediatric Infectious Disease
United Kingdom, Southampton
University of Southampton
United States, Cambridge
Massachusetts Institute of Technology
Shah, Priyen
United Kingdom
Section of Pediatric Infectious Disease
Wilson, Clare M.
United Kingdom
Section of Pediatric Infectious Disease
Broderick, Claire
United Kingdom
Section of Pediatric Infectious Disease
Nijman, Ruud Gerard
United Kingdom
Section of Pediatric Infectious Disease
United Kingdom, London
Imperial College London
Tremoulet, Adriana H.
United States, San Diego
Rady Children's Hospital
Munblit, Daniel Borisovich
United Kingdom, London
National Heart and Lung Institute
Russian Federation, Moscow
Sechenov First Moscow State Medical University
Russian Federation, Moscow
Z.a. Bashlyaeva City Children’s Clinical Hospital
Ulloa-Gutierrez, R.
Costa Rica, San Jose
Caja Costarricense de Seguro Social
Carter, Michael J.
United Kingdom, London
King's College London
De, Tisham
United Kingdom
Section of Pediatric Infectious Disease
Hoggart, Clive J.
United States, New York
Icahn School of Medicine at Mount Sinai
Whittaker, Elizabeth A.
United Kingdom
Section of Pediatric Infectious Disease
United Kingdom, London
Imperial College London
Herberg, Jethro Adam
United Kingdom
Section of Pediatric Infectious Disease
United Kingdom, London
Imperial College London
Kaforou, Myrsini
United Kingdom
Section of Pediatric Infectious Disease
Cunnington, Aubrey J.
United Kingdom, London
Imperial College London
Levin, Michael L.
United Kingdom
Section of Pediatric Infectious Disease
United Kingdom, London
Imperial College London
Vázquez, Jorge Agrimbau
Argentina, Buenos Aires
Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
Carmona, Rodrigo
Argentina, Buenos Aires
Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
Pérez, Laura E.
Argentina, Buenos Aires
Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
Rubiños, Mayra
Argentina, Buenos Aires
Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
Veliz, Natalia
Argentina, Buenos Aires
Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
Yori, Silvana C.
Argentina, Buenos Aires
Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan
Haerynck, Filomeen
Belgium, Ghent
Universitair Ziekenhuis Gent
Hoste, Levi
Belgium, Ghent
Universitair Ziekenhuis Gent
Leal, Izabel Alves
Brazil, Rio de Janeiro
Prontobaby Group
da Silva, André Ricardo Araújo
Brazil, Niteroi
Hospital Municipal Getúlio Vargas Filho
Silva, Anna Esther Araujo
Brazil, Niteroi
Universidade Federal Fluminense
Barchik, Andrea
United States, New York
Icahn School of Medicine at Mount Sinai
Barreiro, Sabrina Teresinha Alvim
Brazil, Niteroi
Hospital Municipal Getúlio Vargas Filho
Cochrane, Natalia
Brazil, Rio de Janeiro
Prontobaby Group
Teixeira, Cristiane Henriques
United States, New York
Icahn School of Medicine at Mount Sinai
Arauj, Julienne Martins
Brazil, Niteroi
Hospital Municipal Getúlio Vargas Filho
Ossa, Rolando Andres Paternina De La
Brazil, Sao Paulo
Universidade de São Paulo
Vieira, Cristina Souza
Brazil, Rio de Janeiro
Prontobaby Group
Dimitrova, Anna
Bulgaria, Sofia
University Children's Hospital
Ganeva, Margarita
Bulgaria, Sofia
University Children's Hospital
Stefanov, Stefan B.
Bulgaria, Sofia
University Children's Hospital
Telcharova-Mihaylovska, Albena
Bulgaria, Sofia
University Children's Hospital
Biggs, Catherine M.
Canada, Vancouver
The University of British Columbia
Scuccimarri, Rosie
Canada, Montreal
Centre Universitaire de Santé Mcgill
Withington, Davinia E.
Canada, Montreal
Centre Universitaire de Santé Mcgill
Raúl, Bustos B.
Chile, Concepcion
Clínica Sanatorio Alemán
Ampuero, Camila
Chile, Santiago
Hospital Dra. Eloísa Díaz I. de la Florida
Aravena, Javiera
Chile, Santiago
Pontificia Universidad Católica de Chile
Casanova, Daniel
Chile, Santiago
Hospital el Carmen de Maipú
Cruces, Pablo
Chile, Santiago
Hospital el Carmen de Maipú
Chile, Santiago
Universidad Andrés Bello
Chile, Santiago
Lared Network
Chile, Santiago
Universidad Finis Terrae
Díaz, F. R.
Chile, Santiago
Hospital el Carmen de Maipú
Chile, Santiago
Universidad Andrés Bello
Chile, Santiago
Lared Network
García-Salum, Tamara
Chile, Santiago
Pontificia Universidad Católica de Chile
Godoy, Loreto M.
Chile, Santiago
Complejo Asistencial Dr. Sótero Del Río
Medina, Rafael A.
Chile, Santiago
Pontificia Universidad Católica de Chile
Galaz, Gonzalo Valenzuela
Chile, Santiago
Pontificia Universidad Católica de Chile
Avila-Aguero, Maria L.
Costa Rica, San Jose
Caja Costarricense de Seguro Social
United States, New Haven
Yale University
Brenes-Chacón, Helena
Costa Rica, San Jose
Caja Costarricense de Seguro Social
Ivankovich-Escoto, Gabriela
Costa Rica, San Jose
Caja Costarricense de Seguro Social
Yock-Corrales, Adriana
Costa Rica, San Jose
Caja Costarricense de Seguro Social
Badib, Adham
Egypt, Alexandria
Smouha International Hospital
Badreldin, Karim
Egypt, Alexandria
Smouha International Hospital
Elkhashab, Yara
Egypt, Alexandria
Smouha International Hospital
Heshmat, Hassan
Egypt, Alexandria
Smouha International Hospital
Heinonen, Santtu
France, Paris
Hôpital Necker Enfants Malades
Angoulvant, François
France, Paris
Centre de Recherche Des Cordeliers
Belot, Alexandre
France, Lyon
Centre International de Recherche en Infectiologie
Ouldali, Naïm
France, Paris
Hôpital Robert-debré Ap-hp
France, Creteil
Activ
France, Paris
Inserm
Beske, Florian
Germany, Oldenburg
Universität Oldenburg
Heep, Axel
Germany, Oldenburg
Universität Oldenburg
Masjosthusmann, Katja
Germany, Munster
Universitätsklinikum Münster
Reiter, Karl
Germany, Tubingen
University Hospital for Women
Heuvel, Ingeborg Van Den
Germany, Munster
Universitätsklinikum Münster
Both, Ulrich Von
Germany, Tubingen
University Hospital for Women
Agrafiotou, Aikaterini
Greece, Athens
Iaso
Antachopoulos, Charalampos T.
Greece, Athens
Hippokration General Hospital
Eleftheriou, Irini
Unknown Affiliation
Farmaki, Evangelia
Greece, Athens
Hippokration General Hospital
Fotis, Lampros
Greece, Athens
Iaso
Greece, Athens
Athens General Hospital
Greece, Piraeus
Metropolitan General Hospital
Kafetzis, Dimitrios
Greece, Piraeus
Metropolitan General Hospital
Lampidi, Stavroula
Unknown Affiliation
Liakopoulou, Theodota
Costa Rica, San Jose
Caja Costarricense de Seguro Social
Greece, Athens
Iaso
Maritsi, Despoina N.
Unknown Affiliation
Michailidou, Elisa
Finland, Helsinki
Children's Hospital Helsinki
Greece, Athens
Hippokration General Hospital
Milioudi, Maria
Greece, Athens
Hippokration General Hospital
Mparmpounaki, Ioanna
Greece, Athens
Iaso
Papadimitriou, Eleni
Greece, Athens
Hippokration General Hospital
Papaevangelou, Vana G.
Greece, Athens
Athens General Hospital
Roilides, Emmanuel J.
Greece, Athens
Hippokration General Hospital
Hong Kong
Queen Mary Hospital Hong Kong
Tsiatsiou, Olga
Greece, Athens
Hippokration General Hospital
Tsolas, Georgios
Greece, Piraeus
Metropolitan General Hospital
Tsolia, Maria N.
Unknown Affiliation
Vantsi, Petrina
Greece, Athens
Iaso
Pineda, Linda Yajeira Banegas
Honduras, San Pedro Sula
North Hospital
Aguilar, Karla Leversia Borjas
Honduras, Tegucigalpa
Hospital Maria
Quintero, Edwin Mauricio Cantillano
Honduras, San Pedro Sula
North Hospital
Ip, Pak Keung Patrick
Honduras, Tegucigalpa
Hospital Maria
Kwan, Mike Yat Wah
Hong Kong, Hong Kong
The University of Hong Kong
Kwok, Janette Siu Yin
Hong Kong, Hong Kong
The University of Hong Kong
Lau, Yu Lung
Honduras, Tegucigalpa
Hospital Maria
To, Kelvin Kai Wang
China, Hong Kong
Hong Kong Hospital Authority
Wong, Joshua Sung Chih
Hong Kong, Hong Kong
The University of Hong Kong
Buonsenso, Danilo
Italy, Rome
Fondazione Policlinico Universitario Agostino Gemelli Irccs
Cimaz, Rolando G.
Italy, Milan
Università Degli Studi Di Milano
D'Argenio, Patrizia
Italy, Bologna
Irccs Azienda Ospedaliero-universitaria Di Bologna
Fabi, Marianna
Unknown Affiliation
Mauro, Angela
Unknown Affiliation
Romani, Lorenza
Italy, Milan
Università Degli Studi Di Milano
Simonini, Gabriele
Italy, Bologna
Irccs Azienda Ospedaliero-universitaria Di Bologna
Valentini, Piero
Italy, Rome
Fondazione Policlinico Universitario Agostino Gemelli Irccs
Pace, David
Malta, Valletta
Mater Dei Hospital
Torpiano, Paul
Malta, Valletta
Mater Dei Hospital
Norero, Ximena
Panama, Panama City
Hospital Del Niño Dr. José Renán Esquivel
Rojas-Bonilla, Magda Ivonne
Unknown Affiliation
Alexeeva, Ekaterina I.
Poland, Warsaw
Medical University of Warsaw
Bobkova, Polina A.
Russian Federation, Moscow
Z.a. Bashlyaeva City Children’s Clinical Hospital
Borzakova, S. N.
Russian Federation, Moscow
Sechenov First Moscow State Medical University
Mazankova, L. N.
Unknown Affiliation
Osmanov, Ismail Magomedovich
Russian Federation, Moscow
Z.a. Bashlyaeva City Children’s Clinical Hospital
Russian Federation, Moscow
Pirogov Russian National Research Medical University Rnrmu
Samitova, Elmira R.
Russian Federation, Moscow
Z.a. Bashlyaeva City Children’s Clinical Hospital
Spiridonova, Ekaterina
Russian Federation, Moscow
Sechenov First Moscow State Medical University
Russian Federation, Moscow
Ministry of Health of Russian Federation
Zholobova, Elena Spartakovna
Russian Federation, Moscow
Sechenov First Moscow State Medical University
Grasa Lozano, C. D.
Spain, Madrid
Hospital Universitario la Paz
Martinón-Torres, Federico
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Méndez-Echevarría, Ana María
Spain, Madrid
Hospital Universitario la Paz
Rivero, Irene
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Rivière, Jacques G.
Spain, Barcelona
Hospital Universitari Vall D'hebron
Rojo, Pablo
Spain, Madrid
Instituto de Investigación Hospital 12 de Octubre
Soler-Palacín, P.
Spain, Barcelona
Hospital Universitari Vall D'hebron
Soriano-Arandes, Antoni
Spain, Barcelona
Hospital Universitari Vall D'hebron
Tagarro-García, Alfredo
Spain, Madrid
Instituto de Investigación Hospital 12 de Octubre
Brodin, Petter
Sweden, Solna
Science for Life Laboratory
Horne, Anna Carin
Sweden, Stockholm
Karolinska Institutet
Brotschi, Barbara
Switzerland, Zurich
Universität Zürich
Prader, Seraina
Switzerland, Zurich
Universität Zürich
Schlapbach, Luregn J.
Switzerland, Zurich
Universität Zürich
Trück, Johannes
Switzerland, Zurich
Universität Zürich
Ketharanathan, Naomi
Netherlands, Rotterdam
Erasmus Mc
Vermont, Clementien L.
Netherlands, Rotterdam
Erasmus Mc
Erdeniz, Emine Hafize
Turkey, Samsun
Ondokuz Mayis Üniversitesi
Volokha, Alla P.
Ukraine, Kyiv
Shupyk National Healthcare University of Ukraine
Akomolafe, Toju
United Kingdom, London
Imperial College Healthcare Nhs Trust
Al-Abadi, Eslam
United Kingdom, Birmingham
Birmingham Children's Hospital
Bamford, A. R.J.
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Boleti, Olga D.
United Kingdom, London
Imperial College Healthcare Nhs Trust
Carrol, Enitan D.
United Kingdom, Liverpool
University of Liverpool
Davies, Patrick R.F.
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Emonts, Marieke
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
United Kingdom, Newcastle
Newcastle University
Evans, Ceri
United Kingdom, Birmingham
Birmingham Women’s and Children’s Nhs Foundation Trust
Fidler, Katy J.
United Kingdom, Brighton
The Royal Alex Children’s Hospital
Foster, Caroline J.
United Kingdom, London
Imperial College Healthcare Nhs Trust
Grandjean, Louis
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Hacohen, Yael
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Hassell, Jane
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Johnson, Sarah R.
United Kingdom, London
Imperial College Healthcare Nhs Trust
Kampmann, Beate B.
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Lillie, Jon
United Kingdom, London
King's College London
Lyall, Hermione
United Kingdom, London
Imperial College Healthcare Nhs Trust
Nadel, Simon
United Kingdom, London
Imperial College Healthcare Nhs Trust
Prendergast, Andrew J.
United Kingdom, London
Barts Health Nhs Trust
Ramnarayan, Padmanabhan
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Riordan, Andrew F.
United Kingdom, Liverpool
Alder Hey Children's Hospital
Rodrigues, Charlene M.C.
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Romaine, Sam T.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Seddon, James Alexander
United Kingdom, London
Imperial College Healthcare Nhs Trust
Shingadia, Delane V.
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Taylor, Andrew Mayall
United Kingdom, Birmingham
Birmingham Women’s and Children’s Nhs Foundation Trust
Tudor-Williams, Gareth
United Kingdom, London
Imperial College Healthcare Nhs Trust
van der Velden, Fabian Johannes Stanislaus
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
United Kingdom, Newcastle
Newcastle University
Wellman, Paul A.
United Kingdom, London
King's College London
Yeung, Shunmay M.
United Kingdom, London
Imperial College Healthcare Nhs Trust
Burns, Jane C.
United States, San Diego
Rady Children's Hospital
Langs-Barlow, Allison
Unknown Affiliation
Mann, Kelly
Unknown Affiliation
Ramirez, Kacy Alyne
Unknown Affiliation
Sayed, Imran Ali
United States, Colorado Springs
University of Colorado at Colorado Springs
Kandawasvika, Gwendoline Quintoline
Zimbabwe, Harare
University of Zimbabwe
Statistics
Citations: 228
Authors: 175
Affiliations: 113
Identifiers
Doi:
10.1056/NEJMoa2102968
ISSN:
00284793
Research Areas
Covid
Maternal And Child Health
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative