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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Blood pressure variability and leukoaraiosis in acute ischemic stroke
International Journal of Stroke, Volume 13, No. 5, Year 2018
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Description
Higher blood pressure, blood pressure variability, and leukoaraiosis are risk factors for early adverse events and poor functional outcome after ischemic stroke, but prior studies differed on whether leukoaraiosis was associated with blood pressure variability, including in ischemic stroke. In the Third International Stroke Trial, blood pressure was measured in the acute phase of ischemic stroke immediately prior to randomization, and at 0.5, 1, and 24 h after randomization. Masked neuroradiologists rated index infarct, leukoaraiosis, and atrophy on CT using validated methods. We characterized blood pressure variation by coefficient of variance and three other standard methods. We measured associations between blood pressure, blood pressure variability, and leukoaraiosis using generalized estimating equations, adjusting for age, and a number of covariates related to treatment and stroke type/severity. Among 3017 patients, mean (±SD) systolic and diastolic blood pressure decreased from 155(±24)/82(±15) mmHg pre-randomization to 146(±23)/78(±14) mmHg 24 h later (P < 0.005). Mean within-subject coefficient of variance was 0.09 ± 0.05 for systolic and 0.11 ± 0.06 for diastolic blood pressure. Patients with most leukoaraiosis were older and had higher blood pressure than those with least (P < 0.0001). Although statistically significant in simple pairwise comparisons, no measures of blood pressure variability were associated with leukoaraiosis when adjusting for confounding variables (P > 0.05), e.g. age. Our results suggest that blood pressure variability is not a potential mechanism to explain the association between leukoaraiosis and poor outcome after acute stroke. © 2017, 2017 World Stroke Organization.
Authors & Co-Authors
Dickie, David Alexander
United Kingdom, Glasgow
University of Glasgow
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Scottish Imaging Network
Aribisala, Benjamin Segun
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Scottish Imaging Network
Berge, Eivind
Norway, Oslo
Oslo Universitetssykehus
Lindley, Richard Iain
Australia, Sydney
George Institute for Global Health
Sandercock, Peter A.G.
United Kingdom, Edinburgh
The University of Edinburgh
Peeters, André Philippe
Belgium, Brussels
Cliniques Universitaires Saint-luc
Cala, Lesley Ann
Australia, Perth
The University of Western Australia
Morris, Zoe
United Kingdom, Edinburgh
Nhs Lothian
Adami, Alessandro
Italy, Verona
Ospedale Sacro Cuore Don Calabria
Wardlaw, Joanna M.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Scottish Imaging Network
Statistics
Citations: 5
Authors: 10
Affiliations: 13
Identifiers
Doi:
10.1177/1747493017729267
ISSN:
17474930
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial