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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
economics, econometrics and finance
Development of a multivariable model to predict medication non-adherence risk factor for patients with acute coronary syndrome
Journal of Pharmaceutical Health Services Research, Volume 12, No. 2, Year 2021
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Description
Objective The aim of this study was to develop a risk prediction model for non-adherence to prescribed medication based on self-reported risk factors in patients with the acute coronary syndrome (ACS). MethodsThis is a prospective follow-up cohort study of 210 patients with ACS at a tertiary hospital in Al Ain city in the United Arab Emirates. Patients with ACS in the electronic registry who were discharged from the hospital but continued to attend outpatient clinics and were prescribed evidence-based medications were identified and interviewed. Univariate and multivariate logistic regression models were constructed and used as appropriate. SPSS V24 was used for data analysis. Key findings A final predictive model of eight variables was developed for ACS medication nonadherence.The significant predicted risk factors identified in the final model with their odds ratios (ORs) and confidence intervals (CIs) were as follows: poor knowledge of prescribed medications (OR = 1.81; CI = 1.032–3.34; P = 0.010), five or more prescribed medicines (OR = 4.97; CI = 1.98–2.49; P = 0.007), more than twice daily dosing regimen (OR = 2.21; CI = 1.04–4.67; P = 0.039), unpleasant side-effects (OR = 2.97; CI = 1.98–2.49; P = 0.007), patients believed that side-effects were the cause of health problems (OR = 4.28; CI = 1.78–10.39; P = 0.001), patients undertaking regular exercise (OR = 2.14; CI = 1.06–4.32; P = 0.035), and comorbid diabetes (OR = 1.97; CI = 1.00–3.87; P = 0.049). Conclusion This study indicates poor knowledge, polypharmacy and comorbidity as risk factors associated with medication non-adherence among patients with ACS. Identification of predictors of non-adherence and strategies has the potential to reduce non-adherence dramatically. © The Author(s) 2021. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved.
Authors & Co-Authors
Sadeq, Adel Shaban
United Arab Emirates, Al Ain
Al Ain University
Elnour, Asim Ahmed
United Arab Emirates, Al Ain
Al Ain University
Hamrouni, A. M.
United Arab Emirates, Al Ain
Al Ain University
Baraka, Mohamed A.
United Arab Emirates, Al Ain
Al Ain University
Egypt, Cairo
Al-azhar University
Al Meslamani, Ahmad Z.
United Arab Emirates, Al Ain
Al Ain University
Adel, Asil
Ireland, Dublin
Trinity College Dublin
Kaabi, Maisoun Al
United Arab Emirates, Abu Dhabi
Seha
Mohamed Ibrahim, Osama H.
United Arab Emirates, Sharjah
University of Sharjah
Egypt, Giza
Cairo University
Al Mazrouei, Nadia
United Arab Emirates, Sharjah
University of Sharjah
Statistics
Citations: 1
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1093/jphsr/rmab005
ISSN:
17598885
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative