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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High prevalence of Mycobacterium tuberculosis infection and disease in children and adolescents with type 1 diabetes mellitus
International Journal of Tuberculosis and Lung Disease, Volume 13, No. 7, Year 2009
Notification
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Description
SETTING: Western Cape Province, South Africa. OBJECTIVES: To describe the prevalence of tuberculosis (TB) infection and disease in children with type 1 diabetes and to investigate the association between glycaemic control and prevalence of TB infection and disease. DESIGN: Cross-sectional hospital-based study conducted at two public referral hospitals. All children and adolescents (aged <21 years) with type 1 diabetes underwent a Mantoux tuberculin skin test (≥10 mm classified as Mycobacterium tuberculosis infection), measurement of glycosylated haemoglobin and a chest radiograph. Patients with symptoms suggestive of TB were investigated using mycobacterial culture. Radiologically and/or bacteriologically confirmed disease was classified as TB disease. RESULTS: Of 291 eligible patients, 258 (88.7%) were included (58% female). The prevalence of M. tuberculosis infection was 29.8% (95%CI 24.2-35.4); nine patients were diagnosed with prevalent TB disease (point prevalence disease 3488 per 100000 population). Poor glycaemic control (hazard ratio 1.39, 95%CI 1.18-1.63 per unit increase in glycated haemoglobin [HbA1c]) and contact with a TB source case (P = 0.0011) was associated with prevalent TB disease. CONCLUSIONS: There is a high prevalence of TB disease in diabetic children and adolescents in this setting. Routine TB screening of children with type 1 diabetes may be indicated in settings highly endemic for TB. Preventive treatment should be considered for diabetic children with proof of TB exposure and/or infection. © 2009 The Union.
Authors & Co-Authors
Webb, Emma A.
South Africa, Tygerberg
Tygerberg Hospital
South Africa, Cape Town
University of Cape Town
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Hesseling, Anneke Catharina
South Africa, Tygerberg
Tygerberg Hospital
Schaaf, Hendrik Simon
South Africa, Tygerberg
Tygerberg Hospital
Gie, Robert Peter
South Africa, Tygerberg
Tygerberg Hospital
Lombard, Carl J.
South Africa, Tygerberg
South African Medical Research Council
Spitaels, Ariane
South Africa, Cape Town
University of Cape Town
Delport, Steven
South Africa, Cape Town
University of Cape Town
Marais, Ben J.
South Africa, Tygerberg
Tygerberg Hospital
Donald, Kirsten A.
South Africa, Cape Town
University of Cape Town
Hindmarsh, Peter Christopher
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Beyers, Nulda
South Africa, Tygerberg
Tygerberg Hospital
Statistics
Citations: 11
Authors: 11
Affiliations: 5
Identifiers
ISSN:
10273719
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
South Africa
Participants Gender
Female