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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis
European Journal of Medicinal Chemistry, Volume 70, Year 2013
Notification
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Description
Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are leading factors in the resurgence of TB cases and the need to produce new agents to combat such infection. Herein, we describe Co(II) and Cu(II) metal based complexes that feature the pyrophosphate ligand with notable selectivity and marked potency against Mycobacteriumtuberculosis, including MDR strains. Such complexes are confirmed to be bacteriocidal and not affected by efflux inhibitors. Finally, while susceptibility to copper has recently been established for M. tuberculosis, the greater efficacy of cobalt observed herein is of considerable note and in line with the discovery of a copper metallothionein in M. tuberculosis. © 2013 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Hoffman, Amanda E.
United States, Syracuse
Syracuse University
DeStefano, Michelle
United States, Syracuse
Syracuse va Medical Center
Shoen, Carolyn M.
United States, Syracuse
Syracuse va Medical Center
Gopinath, Krishnamurthy
South Africa, Cape Town
University of Cape Town
Warner, Digby F.
South Africa, Cape Town
University of Cape Town
Cynamon, Michael Henry
United States, Syracuse
Syracuse va Medical Center
Doyle, Robert P.
United States, Syracuse
Syracuse University
United States, Syracuse
Syracuse va Medical Center
Statistics
Citations: 7
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.ejmech.2013.10.044
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Infectious Diseases