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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Developmental regulatin of RNA editing and polyadenylation in four life cycle stages of Trypanosoma congolense
Molecular and Biochemical Parasitology, Volume 68, No. 2, Year 1994
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Description
The accumulation of many edited mRNAs is developmentally regulated in a transcript-specific fashion in Trypanosoma brucei. In addition, these transcripts are frequently present in two size clases which differ substantially in the lengths of their poly(A) tails, and poly(A) tail length is also developmentally regulated. Previously, these phenomena have only been studied in the mammalian bloodstream and insect procyclic forms (BF and PF, respectively) of T. brucei. In this paper, we examine developmental regulatino of edited RNA abundance and poly(A) tail length of 3 mitochondrially encoded RNAs in mammalian BF and 3 insect stages (PF, epimastigotes, and metacyclics) of T. congolense. T. congolense BF and PF are similar, but not identical, to these stages of T. brucei with regard to edited RNA accumulation and poly(A) tail length. At the level of edited RNA, both epimastigotes and metacyclic stage parasites appear to be pre-adapted for the respiratory mechanisms of BF but not yet down-regulated from the cytochrome-based respiration of PF since edited RNAs encoding NADH dehydrogenase components are up-regulated and edited CYb RNA is abundant in these stages. Poly(A) tail lengths of mitochondrial mRNAs appear to be regulated independently of edited RNA abundace. These results indicate that multiple mechanisms for regulation of mitochondrial gene expression are active throughout the trypanosome life cycle. © 1994.
Authors & Co-Authors
Read, Laurie K.
United States, Seattle
Seattle Biomedical Research Institute
Stankey, Kimberly A.
United States, Seattle
Seattle Biomedical Research Institute
Fish, Wallace R.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Muthiani, Anthony M.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Stuart, Kenneth D.
United States, Seattle
Seattle Biomedical Research Institute
United States, Seattle
University of Washington
Statistics
Citations: 33
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/0166-6851(94)90174-0
ISSN:
01666851
Research Areas
Genetics And Genomics