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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Contrasting neuroendocrine responses in depression and chronic fatigue syndrome
Journal of Affective Disorders, Volume 34, No. 4, Year 1995
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Description
Hypothalamic-pituitary-adrenal (HPA) axis and central 5-HT function were compared in chronic fatigue syndrome (CFS), depression and healthy states. 10 patients with CFS and 15 patients with major depression were matched for age, weight, sex and menstrual cycle with 25 healthy controls. Baseline-circulating cortisol levels were highest in the depressed, lowest in the CFS and intermediate between the two in the control group (P = 0.01). Prolactin responses to the selective 5-HT-releasing agent d-fenfluramine were lowest in the depressed, highest in the CFS and intermediate between both in the healthy group (P = 0.01). Matched pair analysis confirmed higher prolactin responses in CFS patients than controls (P = 0.05) and lower responses in depressed patients than controls (P = 0.003). There were strong inverse correlations between prolactin and cortisol responses and baseline cortisol values. These data confirm that depression is associated with hypercotisolaemia and reduced central 5-HT neurotransmission and suggest that CFS may be associated with hypocortisolaemia and increased 5-HT function. The opposing responses in CFS and depression may be related to reversed patterns of behavioural dysfunction seen in these conditions. These findings attest to biological distinctions between these disorders. © 1995.
Authors & Co-Authors
Cleare, Anthony J.
United Kingdom, London
South London and Maudsley Nhs Foundation Trust
Allain, Theresa Jane
United Kingdom, London
King's College Hospital
Wessely, Simon Charles
United Kingdom, London
King's College Hospital
Murray, Robin M.
United Kingdom, London
King's College Hospital
Statistics
Citations: 244
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/0165-0327(95)00026-J
ISSN:
01650327
Research Areas
Mental Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial