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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients
International Journal of Cancer, Volume 119, No. 6, Year 2006
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Description
Variations in genetic mutations in pancreatic carcinoma between different populations have not been studied extensively, especially in developing countries where pancreatic cancer is rare. We studied the molecular pathology of 44 pancreatic carcinomas from patients residing in a heavily polluted region in the Nile River delta and compared the findings with tumors from 44 United States (US) patients. We evaluated K-ras mutations in codon 12, p53 mutations in exons 5-8, and Gadd45a mutations in exons 1 and 4. Overall, rates of K-ras, p53 and Gadd45 mutations were not statistically different in tumors of patients from Egypt and the US (67.4 vs. 63.4%; 27.3 vs. 36.4% and 9.1 vs. 4.5%, respectively). However, there were distinct differences in the specific types of K-ras and p53 mutations between the 2 groups. In K-ras, G → T transversion mutation was more frequent in the tumors from Egypt than from the US (58.6 vs. 26.9%), whereas G → C transversion was detected in 26.9% of US tumors but none from Egypt (p = 0.003). We also found a trend toward differences in the p53 exons in which mutations occurred, with higher frequency of exon 5 mutation and lower frequency of exon 6 mutation in Egyptian tumors. Logistic regression showed that K-ras G → T transversion mutations and p53 exon 6 mutations were predicted by the country of residence of the patients. Our study identifies that there are differences in the types of mutations found in tumors from pancreatic carcinoma patients in Egypt and the US, and suggests that environmental factors may explain these differences. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Soliman, Amr S.
United States, Ann Arbor
University of Michigan School of Public Health
United States, Ann Arbor
University of Michigan, Ann Arbor
Bondy, Melissa L.
United States, Houston
University of Texas Health Science Center at Houston
Webb, Charity Renee
United States, Houston
University of Texas Health Science Center at Houston
Schottenfeld, David
United States, Ann Arbor
University of Michigan School of Public Health
Bonner, Joseph
United States, Ann Arbor
University of Michigan School of Public Health
El-Ghawalby, Nabieh A.
United States, Houston
University of Texas Health Science Center at Houston
Soultan, Ahmed
United States, Houston
University of Texas Health Science Center at Houston
Abd Elwahab, M. M.
United States, Houston
University of Texas Health Science Center at Houston
Fathy, Omar Mohammed
United States, Houston
University of Texas Health Science Center at Houston
Ebidi, Gamal
United States, Houston
University of Texas Health Science Center at Houston
Zhang, Qing
United States, Houston
University of Texas Health Science Center at Houston
Greenson, Joel Kasle
United States, Ann Arbor
University of Michigan Medical School
Abbruzzese, James L.
Egypt, Mansoura
Gastrointestinal Surgery Center
Hamilton, Stanley R.
United States, Houston
University of Texas Health Science Center at Houston
Statistics
Citations: 20
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1002/ijc.21986
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Genetics And Genomics
Study Locations
Egypt