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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin a in HIV-1-exposed infants in Kenya
Clinical and Experimental Immunology, Volume 153, No. 1, Year 2008
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Description
Humoral immunity, and specifically immunoglobulin A (IgA) that is directed against human immunodeficiency virus (HIV)-1, may contribute to protection against HIV-1 acquisition at mucosal surfaces. HIV-1-specific IgA has been detected in genital tract secretions of HIV-1-uninfected commercial sex workers with HIV-1 exposure, and may be produced in parotid saliva by infants exposed orally to HIV-1 during delivery and breastfeeding. To explore this hypothesis, we collected saliva from 145 infants aged ≤ 6 months enrolled in a perinatal HIV-1 transmission study in Nairobi and from 55 control infants without HIV-1 exposure who were born to HIV-1-seronegative mothers. Among the 145 infants, 115 (79%) remained uninfected during the 12-month study period and 30 (21%) became HIV-1-infected during follow-up. Nine (8%) of the 115 HIV-1-exposed, uninfected infants had detectable levels of HIV-1 gp160-specific IgA compared with four (13%) of 30 infected infants and none of 55 control infants (P = 0.47 and P = 0.03 respectively). Among the nine HIV-1-exposed, uninfected infants with positive assays, median age was 1 month and none acquired HIV-1 during follow-up. We conclude that HIV-1-specific salivary IgA responses may be generated by very young infants exposed perinatally to maternal HIV-1. Mucosal responses would be an appropriate target for paediatric vaccines against breast milk HIV-1 transmission. © 2008 British Society for Immunology.
Authors & Co-Authors
Farquhar, Carey
United States, Seattle
University of Washington
VanCott, Thomas C.
United States, Kensington
Advanced Bioscience Laboratories, Inc.
Bosire, Rose Kerubo
Kenya, Nairobi
University of Nairobi
Bermudez, C.
United States, Rockville
Hjf
Mbori-Ngacha, Dorothy A.
Kenya, Nairobi
University of Nairobi
Lohman-Payne, Barbara L.
United States, Seattle
University of Washington
Kenya, Nairobi
University of Nairobi
Nduati, Ruth W.
Kenya, Nairobi
University of Nairobi
Otieno, Phelgona Apondi O.
Kenya, Nairobi
University of Nairobi
John-Stewart, Grace C.
United States, Seattle
University of Washington
Statistics
Citations: 24
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-2249.2008.03664.x
ISSN:
00099104
e-ISSN:
13652249
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Kenya