Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Expression and role of CXCL10 during the encephalitic stage of experimental and clinical african trypanosomiasis
Journal of Infectious Diseases, Volume 200, No. 10, Year 2009
Notification
URL copied to clipboard!
Description
Background: Human African trypanosomiasis, caused by Trypanosoma brucei, involves an early hemolymphatic stage followed by a late encephalitic stage. Methods: We studied the expression of chemokines with use of microarray and enzyme-linked immunosorbent assay in T. brucei brucei-infected mice and in patients with human African trypanosomiasis and examined their role in controlling brain accumulation of T cells and parasites. Results: The messenger RNAs (mRNAs) encoding CXCR3 ligands CXCL9 and CXCL10 demonstrated the greatest increases among chemokines in brain specimens of infected mice, as determined by microarray. CXCL9 and CXCL10 mRNA accumulation was interferon (IFN)-γ-dependent. Expression of CXCL10 was predominantly observed in astrocytes. Weight loss was registered in wild-type but not in CXCL10 -/- and CXCR3-/- infected mice. Infected CXCL10 -/- or CXCR3-/- mice demonstrated reduced accumulation of trypanosomes and T cells in the brain parenchyma but similar parasitemia levels, compared with wild-type mice. CXCL10 and IFN-γ levels were increased in the cerebrospinal fluid of patients with late stage but not early stage human African trypanosomiasis. Levels of CXCL10 in patients with late stage human African trypanosomiasis were associated with somnolence, low body weight, and trypanosomes in the cerebrospinal fluid. Conclusion. IFN- γ-dependent CXCL10 is critical for accumulation of T cells and trypanosomes in the brain during experimental African trypanosomiasis. Data suggest CXCL10 as a candidate marker for late stage human African trypanosomiasis © 2009 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Amin, Daniel Ndem
Unknown Affiliation
Rottenberg, M. Enrique
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Thomsen, Allan R.
Denmark, Copenhagen
Københavns Universitet
Mumba Ngoyi, Dieudonné
Democratic Republic Congo, Gombe, Kinshasa
Institut National de Recherche Biomédicale
Fenger, Christina D.
Denmark, Odense
Syddansk Universitet
Kristensson, Krister S.
Unknown Affiliation
Büscher, Philippe
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Finsen, Bente
Denmark, Odense
Syddansk Universitet
Masocha, Willias
Kuwait, Kuwait City
Kuwait University
Statistics
Citations: 81
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1086/644597
ISSN:
00221899