Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
FLOTAC: a new sensitive technique for the diagnosis of hookworm infections in humans
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 102, No. 1, Year 2008
Notification
URL copied to clipboard!
Description
Hookworms infect more than 10% of the world's population, but current diagnostic tools have drawbacks. Our objective was to compare the diagnostic performance of three methods (Kato-Katz, ether concentration and FLOTAC techniques) for hookworm diagnosis. Stool samples were obtained from 102 schoolchildren in Côte d'Ivoire. First, a duplicate 41.7 mg Kato-Katz thick smear was prepared. Next, a small portion of stool (mean weight 1.8 g) was preserved in sodium acetate-acetic acid-formalin and forwarded to a European laboratory. These samples were split in three parts, one processed by an ether concentration technique and two by the FLOTAC technique. All samples were examined by experienced technicians for hookworm eggs using light microscopy. The observed hookworm prevalences as assessed by the FLOTAC, Kato-Katz and ether concentration techniques were 65.7%, 51.0% and 28.4%, respectively. Considering the combined results as the diagnostic 'gold' standard, the FLOTAC technique had a sensitivity of 88.2% compared with 68.4% for the Kato-Katz and 38.2% for the ether concentration techniques. The Kato-Katz method resulted in a significantly higher mean number of eggs per gram of stool (155.8 EPG) compared with the FLOTAC (37.7 EPG) and ether concentration (5.7 EPG) methods. The FLOTAC method shows promise as an important new tool for individual hookworm diagnosis and for rigorous monitoring of helminth control programmes. [Clinical Trial No. ISRCTN21782274]. © 2007 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Utzinger, Jürg
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Rinaldi, Laura
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Lohourignon, Laurent K.
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Rohner, Fabian
Switzerland, Zurich
Eth Zürich
Cote D'ivoire, Abidjan
Centre Suisse de Recherches Scientifiques Abidjan
Zimmermann, Michaël Bruce
Switzerland, Zurich
Eth Zürich
Tschannen, Andres B.
Cote D'ivoire, Abidjan
Centre Suisse de Recherches Scientifiques Abidjan
N'Goran, Eliézer Kouakou
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Centre Suisse de Recherches Scientifiques Abidjan
Cringoli, Giuseppe
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Statistics
Citations: 135
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/j.trstmh.2007.09.009
ISSN:
00359203
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Ivory Coast