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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Straightening out the LINEs: LINE-1 orthologous loci
Genomics, Volume 85, No. 2, Year 2005
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Description
The L1Hs preTa subfamily of long interspersed elements (LINEs) originated after the divergence of human and chimpanzee and is therefore found only in the human genome. Thirty-three of the 254 L1Hs preTa elements are polymorphic for the absence/presence of the insertion, making them useful markers for studying human population genetics. The problem of homoplasy, however, can diminish the value of LINEs as phylogenetic and population genetic markers. We examined anomalous orthologous sites in a range of nonhuman primates. Only two cases of other mobile elements inserting near the preintegration sites of L1Hs preTa elements were observed: an AluY insertion in Chlorocebus and an L1PA8 insertion in Aotus. Sequence analysis showed that both elements were clearly distinguishable from their human counterparts. We conclude that L1 elements can continue to be regarded as essentially homoplasy-free genetic characters. © 2004 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Ho, Huei Jin
United States, Baton Rouge
Louisiana State University
Ray, David A.
United States, Baton Rouge
Louisiana State University
Salem, Abdel Halim
United States, Baton Rouge
Louisiana State University
Egypt, Ismailia
Faculty of Medicine
Myers, Jeremy S.
United States, Baton Rouge
Louisiana State University
United States, Nashville
Vanderbilt University
Batzer, Mark A.
United States, Baton Rouge
Louisiana State University
Statistics
Citations: 16
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.ygeno.2004.10.016
ISSN:
08887543
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study