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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Brain volumes in psychotic youth with schizophrenia and mood disorders
Journal of Psychiatry and Neuroscience, Volume 35, No. 4, Year 2010
Notification
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Description
Background: We sought to test the hypothesis that deficits in grey matter volume are characteristic of psychotic youth with early-onset schizophrenia-spectrum disorders (EOSS) but not of psychotic youth with early-onset mood disorders (EOMD). Methods: We used magnetic resonance imaging to examine brain volume in 24 psychotic youth (13 male, 11 female) with EOSS (n = 12) or EOMD (n = 12) and 17 healthy controls (10 male, 7 female). We measured the volume of grey and white matter using an automated segmentation program. Results: After adjustment for age and intracranial volume, whole brain volume was lower in the EOSS patients than in the healthy controls (p = 0.001) and EOMD patients (p = 0.002). The EOSS patients had a deficit in grey matter volume (p = 0.005), especially in the frontal (p = 0.003) and parietal (p = 0.006) lobes, with no significant differences in white matter volume. Limitations: The main limitations of our study were its small sample size and the inclusion of patients with depression and mania in the affective group. Conclusion: Adolescents with EOSS have grey matter deficits compared with healthy controls and psychotic adolescents with EOMD. Our results suggest that grey matter deficits are not generally associated with psychosis but may be specifically associated with schizophrenia. Larger studies with consistent methods are needed to reconcile the contradictory findings among imaging studies involving psychotic youth. © 2010 Canadian Medical Association.
Authors & Co-Authors
El-Sayed, Mohammed
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Egypt, Mansoura
Faculty of Medicine
Grant Steen, R.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Poe, Michele D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Carter Bethea, T.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Gerig, Guido
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Salt Lake City
The University of Utah
Lieberman, Jeffrey Alan
United States, New York
Columbia University
Sikich, Linmarie
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 23
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1503/jpn.090051
ISSN:
11804882
Research Areas
Mental Health
Participants Gender
Male
Female