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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Genomic analyses of three malaria vectors reveals extensive shared polymorphism but contrasting population histories
Molecular Biology and Evolution, Volume 31, No. 4, Year 2014
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Description
Anopheles gambiae s.l. are important malaria vectors, but little is known about their genomic variation in the wild. Here, we present inter- and intraspecies analysis of genome-wide RADseq data, in three Anopheles gambiae s.l. species collected from East Africa. The mosquitoes fall into three genotypic clusters representing described species (A. gambiae, A. arabiensis, and A. merus) with no evidence of cryptic breeding units. Anopheles merus is the most divergent of the three species, supporting a recent new phylogeny based on chromosomal inversions. Even though the species clusters are well separated, there is extensive shared polymorphism, particularly between A. gambiae and A. arabiensis. Divergence between A. gambiae and A. arabiensis does not vary across the autosomes but is higher in X-linked inversions than elsewhere on X or on the autosomes, consistent with the suggestion that this inversion (or a gene within it) is important in reproductive isolation between the species. The 2La/2L+a inversion shows no more evidence of introgression between A. gambiae and A. arabiensis than the rest of the autosomes. Population differentiation within A. gambiae and A. arabiensis is weak over approximately 190-270 km, implying no strong barriers to dispersal. Analysis of Tajima's D and the allele frequency spectrum is consistent with modest population increases in A. arabiensis and A. merus, but a more complex demographic history of expansion followed by contraction in A. gambiae. Although they are less than 200 km apart, the two A. gambiae populations show evidence of different demographic histories. © 2014 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3969563/bin/supp_31_4_889__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3969563/bin/supp_msu040_SupplementaryFigures1to9ForMBEresubmission.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3969563/bin/supp_msu040_SupplementaryFigures9to14ForMBEresubmission.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3969563/bin/supp_msu040_SupplementaryResults_and_TablesForMBEresubmission.pdf
Authors & Co-Authors
O'Loughlin, Samantha M.
United Kingdom, London
Imperial College London
Magesa, Stephen Masingili
Tanzania, Tanga
Nimr Amani Research Centre
United States, Research Triangle Park
Rti International
Mbogo, Charles Mwaniki
Kenya, Kilifi
Centre for Geographic Medicine Research
Kenya, Nairobi
Kenyatta National Hospital
Mosha, Franklin W.
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Midega, Janet T.
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, London
Imperial College London
Lomas, Susan
United Kingdom, London
Imperial College London
Burt, Austin
United Kingdom, London
Imperial College London
Statistics
Citations: 42
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1093/molbev/msu040
ISSN:
07374038
e-ISSN:
15371719
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Multi-countries